NCOA2 Mouse Monoclonal Antibody [Clone ID: OTI7G5]
$447.00
In Stock*
Specifications
| Product Data | |
| Clone Name | OTI7G5 |
|---|---|
| Application | WB |
| Recommended Dilution | WB 1:2000 |
| Reactivity | Human, Mouse, Rat |
| Antibody Host | Mouse |
| Isotype | IgG1 |
| Clonality | Monoclonal |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1-280 of human NCOA2 (NP_006531) produced in E.coli. |
| Buffer | PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide |
| Concentration | 1 mg/ml |
| Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Predicted Protein Size | 159 kDa |
| Gene Name | nuclear receptor coactivator 2 |
| Database Link | |
| Background | The NCOA2 gene encodes nuclear receptor coactivator 2, which aids in the function of nuclear hormone receptors. Nuclear hormone receptors are conditional transcription factors that play important roles in various aspects of cell growth, development, and homeostasis by controlling expression of specific genes. Members of the nuclear hormone receptor superfamily, which includes the 5 steroid receptors and class II nuclear receptors (see below), are structurally characterized by 3 distinct domains: an N-terminal transcriptional activation domain, a central DNA-binding domain, and a C-terminal hormone-binding domain. Before the binding of hormone, steroid receptors, which are sometimes called class I of the nuclear hormone receptor family, remain inactive in a complex with heat-shock protein-90 (MIM 140571) and other stress family proteins. Binding of hormone induces critical conformational changes in steroid receptors that cause them to dissociate from the inhibitory complex, bind as homodimers to specific DNA enhancer elements associated with target genes, and modulate that gene's transcription. After binding to enhancer elements, transcription factors require transcriptional coactivator proteins to mediate their stimulation of transcription initiation (Hong et al., 1997 PubMed 9111344). supplied by OMIM, Nov 2010 |
| Synonyms | bHLHe75; GRIP1; KAT13C; NCoA-2; SRC2; TIF2 |
| Reference Data | |
| Protein Categories | Intracellular Proteins, Transciption Factors |
| Protein Families | Druggable Genome |
Reviews
Documents
| Product Manuals |
| FAQs |
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Resources
Other "OTI7G5" antibodies (4)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| CF805128 | Carrier-free (BSA/glycerol-free) NCOA2 mouse monoclonal antibody, clone OTI7G5 (formerly 7G5) | 100 ug |
$620.00
|
|
| TA805128AM | NCOA2 mouse monoclonal antibody, clone OTI7G5 (formerly 7G5), Biotinylated | 100 ul |
$509.00
|
|
| TA805128BM | NCOA2 mouse monoclonal antibody, clone OTI7G5 (formerly 7G5), HRP conjugated | 100 ul |
$509.00
|
|
| TA805128S | NCOA2 mouse monoclonal antibody, clone OTI7G5 (formerly 7G5) | 30 ul |
$200.00
|
|
Citations
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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