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L Kynurenine Hydrolase (KYNU) Mouse Monoclonal Antibody [Clone ID: OTI1H1]

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SKU
TA803959
KYNU mouse monoclonal antibody, clone OTI1H1 (formerly 1H1)
Size:
100 ul 30 ul
Formulation:
Standard Carrier-free
Conjugation:
Unconjugated Biotin HRP
  $447.00
In Stock*
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View other "L Kynurenine Hydrolase or NM_001032998" antibodies

Specifications
Specifications
Product Data
Clone Name OTI1H1
Application IHC
Recommended Dilution IHC 1:150
Reactivity Human, Rat
Antibody Host Mouse
Isotype IgG2b
Clonality Monoclonal
Immunogen Human recombinant protein fragment corresponding to amino acids 1-216 of human KYNU (NP_001028170) produced in E.coli.
Buffer PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide
Concentration 1 mg/ml
Purification Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Shipping Blue Ice
Predicted Protein Size 34.5 kDa
Gene Name kynureninase
Database Link
Background Kynureninase is a pyridoxal-5'-phosphate (pyridoxal-P) dependent enzyme that catalyzes the cleavage of L-kynurenine and L-3-hydroxykynurenine into anthranilic and 3-hydroxyanthranilic acids, respectively. Kynureninase is involved in the biosynthesis of NAD cofactors from tryptophan through the kynurenine pathway. Alternative splicing results in multiple transcript variants. provided by RefSeq, Nov 2010
Synonyms KYNUU
Reference Data
Protein Categories Intracellular Proteins
Protein Families Protease
Protein Pathways Metabolic pathways, Tryptophan metabolism
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Other "OTI1H1" antibodies (4)
SKU Description Size Price
CF803959 Carrier-free (BSA/glycerol-free) KYNU mouse monoclonal antibody, clone OTI1H1 (formerly 1H1) 100 ug
$620.00
TA803959AM KYNU mouse monoclonal antibody, clone OTI1H1 (formerly 1H1), Biotinylated 100 ul
$509.00
TA803959BM KYNU mouse monoclonal antibody, clone OTI1H1 (formerly 1H1), HRP conjugated 100 ul
$509.00
TA803959S KYNU mouse monoclonal antibody, clone OTI1H1 (formerly 1H1) 30 ul
$200.00

file-alt Citations

Differential kynurenine pathway metabolism in highly metastatic aggressive breast cancer subtypes: beyond IDO1-induced immunosuppression
Heng, Bilgin, Lovejoy et al
Breast Cancer Res (2020) 22 (1), 113 DOI: 10.1186/s13058-020-01351-1
Cited by 58
AI Summary: In this study, OriGene products—including the KMO and KYNU antibodies—were used for western blot and immunohistochemistry analyses to assess protein expression of key kynurenine pathway enzymes in breast cancer subtypes, enabling the identification of their upregulation in aggressive cancers.
FigureFigureFigure
Differential kynurenine pathway metabolism in highly-metastatic aggressive breast cancer subtypes: beyond IDO1-induced immunosuppression
Heng, Bilgin, Lovejoy et al
Research Square (2020)
Snippet: hour. Blots were probed overnight at 4°C with primary antibodies: IDO1 (1:1000;clone: UMAB126, Origene), KMO (1:1000;LSBio), kynureninase (KYNU) (1:500;clone: OTI1H1, Origene) and actin (1:1000;Abcam). Secondary
WB IHC
Showing 1-2 of 2 papers.
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