Lamin A (LMNA) Mouse Monoclonal Antibody [Clone ID: OTI3F6]
$447.00
In Stock*
Specifications
| Product Data | |
| Clone Name | OTI3F6 |
|---|---|
| Application | IF, WB |
| Recommended Dilution | WB 1:2000 |
| Reactivity | Human, Mouse, Rat |
| Antibody Host | Mouse |
| Isotype | IgG2b |
| Clonality | Monoclonal |
| Immunogen | Full length human recombinant protein of human LMNA (NP_733821) produced in HEK293T cell. |
| Buffer | PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide |
| Concentration | 1 mg/ml |
| Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Predicted Protein Size | 74 kDa |
| Gene Name | lamin A/C |
| Database Link | |
| Background | The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. provided by RefSeq, Apr 2012 |
| Synonyms | CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL; FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC |
| Reference Data | |
| Protein Categories | Cardiovascular diseases, Intracellular Proteins, Nervous system: Neurodegenerative diseases |
| Protein Families | Druggable Genome |
| Protein Pathways | Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM) |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other "OTI3F6" antibodies (4)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| CF803489 | Carrier-free (BSA/glycerol-free) LMNA mouse monoclonal antibody, clone OTI3F6 (formerly 3F6) | 100 ug |
$620.00
|
|
| TA803489AM | LMNA mouse monoclonal antibody,clone 3F6, Biotinylated | 100 ul |
$509.00
|
|
| TA803489BM | LMNA mouse monoclonal antibody,clone 3F6, HRP conjugated | 100 ul |
$509.00
|
|
| TA803489S | LMNA mouse monoclonal antibody, clone OTI3F6 (formerly 3F6) | 30 ul |
$200.00
|
|
Citations
Targeting CAR-T cell senescence through Mysm1-SSBP1 axis improves persistence and therapeutic efficacy
Gao, Zhao, Liu et al
Research Square (2025)
Gao, Zhao, Liu et al
Research Square (2025)
AI Summary: OriGene products, specifically the anti-SSBP1 antibody (TA382030) and anti-Lamin A antibody (TA803489), were used in this study to detect protein expression and investigate the molecular mechanisms underlying improved CAR-T cell persistence and function.
Snippet: i-p21 (CST, 2947), anti-Caspase3 (CST, 9662), anti-Bcl-2 (Bioworld, P10415), anti-Bcl-XL (Proteintech, 10783-AP), anti-Gelsolin (Proteintech, 11644-AP), anti-FMR1 (Proteintech, 13755-AP), anti-SSBP1 (OriGENE, TA382030), anti-Flag (Proteintech, 80801-2-RR), anti-VDAC1 (CST, 4866), anti-HA (CST, 3724), anti-Lamin A (OriGENE, TA803489). After blocking with 5% non-fat milk or bovine serum albumin, the
Showing 1-1 of 1 papers.
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