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FBXW7 Mouse Monoclonal Antibody [Clone ID: OTI6F5]

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SKU
TA802869
FBXW7 mouse monoclonal antibody, clone OTI6F5 (formerly 6F5)
Size:
100 ul 30 ul
Formulation:
Standard Carrier-free
Conjugation:
Unconjugated Biotin HRP
  $447.00
In Stock*
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View other "FBXW7 or NM_033632" antibodies

Specifications
Specifications
Product Data
Clone Name OTI6F5
Application IHC, WB
Recommended Dilution WB 1:2000, IHC 1:150
Reactivity Human, Mouse, Rat
Antibody Host Mouse
Isotype IgG2a
Clonality Monoclonal
Immunogen Human recombinant protein fragment corresponding to amino acids 1-354 of human FBXW7 (NP_361014) produced in E.coli.
Buffer PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide
Concentration 1 mg/ml
Purification Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Shipping Blue Ice
Predicted Protein Size 79.5 kDa
Gene Name F-box and WD repeat domain containing 7
Database Link
Background This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene was previously referred to as FBX30, and belongs to the Fbws class; in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers. Multiple transcript variants encoding different isoforms have been found for this gene. provided by RefSeq, Mar 2012
Synonyms AGO; CDC4; FBW6; FBW7; FBX30; FBXO30; FBXW6; hAgo; hCdc4; SEL-10; SEL10
Reference Data
Protein Categories Growth Factors, Intracellular Proteins
Protein Families Druggable Genome, Transmembrane
Protein Pathways Ubiquitin mediated proteolysis
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Other "OTI6F5" antibodies (4)
SKU Description Size Price
CF802869 Carrier-free (BSA/glycerol-free) FBXW7 mouse monoclonal antibody, clone OTI6F5 (formerly 6F5) 100 ug
$620.00
TA802869AM FBXW7 mouse monoclonal antibody,clone 6F5, Biotinylated 100 ul
$509.00
TA802869BM FBXW7 mouse monoclonal antibody,clone 6F5, HRP conjugated 100 ul
$509.00
TA802869S FBXW7 mouse monoclonal antibody, clone OTI6F5 (formerly 6F5) 30 ul
$200.00

file-alt Citations

PKC-dependent MYRF dysregulation links Aβ pathology to oligodendrocyte, myelin and cognitive alterations in Alzheimer's disease
Balantzategi, Gaminde-Blasco, Alcaniz
bioRxiv (2025)
AI Summary: OriGene’s anti-Fbxw7 antibody (#TA802869S) was used in this study to detect Fbxw7 protein levels, contributing to the investigation of molecular mechanisms underlying Alzheimer's disease pathology.
Snippet: anti-Fbxw7 (ms, 1:1,000;#TA802869S, OriGene), anti-Parkin (ms, 1:1,000;#sc-32282, Santa Cruz), and anti-α-Tubulin (ms, 1:5,000;#ab7291, abcam)
Fbxw7 regulates hepatocellular carcinoma migration and invasion via Notch1 signaling pathway
Wang, Zhang, Zhou et al
Int. J. Oncol. (2015)
Cited by 40
AI Summary: OriGene’s anti-Fbxw7 antibody (TA802869) was used in this study to detect Fbxw7 protein expression in hepatocellular carcinoma tissues, helping to demonstrate its reduced levels and association with cancer progression.
Snippet: 1 h at room temperature. The sections were incubated with anti-Fbxw7 (1:150, TA802869, from OriGene Technologies, Inc., Rockville, MD, USA) in PBS at 4˚C overnight in a moist chamber. The sections were incubated with ... Cite SaveSaving
IHC
Showing 1-2 of 2 papers.
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