BRCA1 Mouse Monoclonal Antibody [Clone ID: OTI2A5]
$447.00
In Stock*
Specifications
| Product Data | |
| Clone Name | OTI2A5 |
|---|---|
| Application | WB |
| Recommended Dilution | WB 1:2000 |
| Reactivity | Human |
| Antibody Host | Mouse |
| Isotype | IgG1 |
| Clonality | Monoclonal |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1151-1473 of human BRCA1 (NP_009225) produced in E.coli. |
| Buffer | PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide |
| Concentration | 1 mg/ml |
| Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Gene Name | BRCA1, DNA repair associated |
| Database Link | |
| Background | This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified. provided by RefSeq, May 2009 |
| Synonyms | BRCA1/BRCA2-containing complex, subunit 1; BRCAI; BRCC1; breast and ovarian cancer susceptibility protein 1; breast cancer 1, early onset; BROVCA1; IRIS; PSCP; RNF53 |
| Reference Data | |
| Protein Categories | Cancer: Gastrointestinal, Cancer: Gynecologic, Cancer: Sarcoma, Cardiovascular diseases, Growth Factors, Intracellular Proteins |
| Protein Families | Druggable Genome, Transcription Factors |
| Protein Pathways | Ubiquitin mediated proteolysis |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other "OTI2A5" antibodies (4)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| CF802628 | Carrier-free (BSA/glycerol-free) BRCA1 mouse monoclonal antibody, clone OTI2A5 (formerly 2A5) | 100 ug |
$620.00
|
|
| TA802628AM | BRCA1 mouse monoclonal antibody,clone 2A5, Biotinylated | 100 ul |
$509.00
|
|
| TA802628BM | BRCA1 mouse monoclonal antibody,clone 2A5, HRP conjugated | 100 ul |
$509.00
|
|
| TA802628S | BRCA1 mouse monoclonal antibody, clone OTI2A5 (formerly 2A5) | 30 ul |
$200.00
|
|
Citations
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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