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KRAS Mouse Monoclonal Antibody [Clone ID: OTI2C1]

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SKU
TA801672S
KRAS mouse monoclonal antibody, clone OTI2C1 (formerly 2C1)
Size:
30 ul 100 ul
Conjugation:
Unconjugated
  $200.00
2 Days*
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Frequently Bought Together (3)

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20 ug
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View other "KRAS or NM_033360" antibodies

Specifications
Specifications
Product Data
Clone Name OTI2C1
Application IHC, Simple Western, WB
Recommended Dilution IHC 1:100, WB 1:2000, Simple Western 1:20-1:50
Simple Western 1:50
Reactivity Human, Mouse, Rat
Antibody Host Mouse
Isotype IgG2b
Clonality Monoclonal
Immunogen Full length human recombinant protein of human KRAS (NP_203524) produced in E.coli.
Buffer PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide
Concentration 1 mg/ml
Purification Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Shipping Blue Ice
Predicted Protein Size 21.5 kDa
Gene Name KRAS proto-oncogene, GTPase
Database Link
Background This gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. Alternative splicing leads to variants encoding two isoforms that differ in the C-terminal region. provided by RefSeq, Jul 2008
Synonyms C-K-RAS; c-Ki-ras2; CFC2; K-RAS2A; K-RAS2B; K-RAS4A; K-RAS4B; KI-RAS; KRAS1; KRAS2; NS; NS3; RALD
Reference Data
Protein Categories ADC Targets, Cancer: Endocrine, Cancer: Gastrointestinal, Cancer: Gynecologic, Cancer: Haematopoietic and Lymphoid, Cancer: Head and Neck, Cancer: Lung, Cancer: Sarcoma, Cancer: Skin, Intracellular Proteins
Protein Families Druggable Genome
Protein Pathways Acute myeloid leukemia, Axon guidance, B cell receptor signaling pathway, Bladder cancer, Chemokine signaling pathway, Chronic myeloid leukemia, Colorectal cancer, Dorso-ventral axis formation, Endometrial cancer, ErbB signaling pathway, Fc epsilon RI signaling pathway, Gap junction, Glioma, GnRH signaling pathway, Insulin signaling pathway, Long-term depression, Long-term potentiation, MAPK signaling pathway, Melanogenesis, Melanoma, Natural killer cell mediated cytotoxicity, Neurotrophin signaling pathway, Non-small cell lung cancer, Pancreatic cancer, Pathways in cancer, Progesterone-mediated oocyte maturation, Prostate cancer, Regulation of actin cytoskeleton, Renal cell carcinoma, T cell receptor signaling pathway, Thyroid cancer, Tight junction, VEGF signaling pathway
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Other "OTI2C1" antibodies (4)
SKU Description Size Price
CF801672 Carrier-free (BSA/glycerol-free) KRAS mouse monoclonal antibody, clone OTI2C1 (formerly 2C1) 100 ug
$620.00
TA801672 KRAS mouse monoclonal antibody, clone OTI2C1 (formerly 2C1) 100 ul
$447.00
TA801672AM KRAS mouse monoclonal antibody,clone 2C1, Biotinylated 100 ul
$509.00
TA801672BM KRAS mouse monoclonal antibody,clone 2C1, HRP conjugated 100 ul
$509.00

file-alt Citations

Endogenous oncogenic KRAS expression increases cell proliferation and motility in near-diploid hTERT RPE-1 cells
Hindul, Abbott, Adan et al
J Biol Chem (2024)
Cited by 7
AI Summary: In this study, the OriGene anti-KRas antibody (mouse monoclonal #CF801672) was used to detect KRas protein levels, enabling the researchers to assess the expression and effects of endogenous oncogenic KRAS mutations on cell proliferation and motility.
Snippet: mouse antibody #10221703, dilution 1/500), anti-pERK (Cell Signalling Technology, rabbit mAb #4370, dilution 1/2000), anti-KRas antibody (OriGene, mouse monoclonal #CF801672, dilution 1/1000), anti-Ras.G12V antibody (Cell signalling technology, rabbit monoclonal #14412, dilution 1/800), anti-γ-tubulin antibody (SIGMA-ALDRICH, mouse monoclonal, #T6557, 1/5000 dilution) and anti-pRb-Ser807/S811 antibody (Cell Signalling Technology, rabbit mAb #8516, 1/1000 dilution ). …
WB
Prpc Glycoprotein Modulates Atmospherically Relevant Artificial Particulate Matter-Induced Development of Lung Cancer
Kook, Kieu, Sim et al
Available at SSRN  (2024)
Snippet: (sc-53136-Santa Cruz Biotechnology), K-ras (TA801672-Origene), Ki67 (ab16667- then incubated with specific primary antibodies against K-ras (TA801672-Origene), 176
Endogenous oncogenic KRAS expression increases cell proliferation and motility in near-diploid hTERT RPE-1 cells
Hindul, Abbott, Adan et al
bioRxiv (2023)
Cited by 1
Snippet: anti-pERK (Cell Signalling Technology, rabbit mAb #4370, dilution 1/2000), anti-KRas antibody (OriGene, mouse monoclonal #CF801672, dilution 1/1000), anti-Ras.G12V antibody (Cell signalling technology, rabbit monoclonal #14412, dilution 1/800),
WB
Mutation-specific effects of NRAS oncogenes in colorectal cancer cells
Kuhn, Klinger, Uhlitz et al
Adv Biol Regul (2021) 79, 100778 DOI: 10.1016/j.jbior.2020.100778
Cited by 12
Mutation-specific effects of NRAS oncogenes in colorectal cancer cells
Kuhn, Klinger, Uhlitz et al
Advances in Biological Regulation (2020) 79, 100778 DOI: 10.1016/j.jbior.2020.100778
Cited by 12
Snippet: Skip to article;pAKT (Ser473) [NEB 4060S, 1:2,000], KRAS [Origene TA801672, 1:2,000],
WB
Reduced replication origin licensing selectively kills KRAS-mutant colorectal cancer cells via mitotic catastrophe
Gastl
Thesis (2018)
Snippet: Page 1. Reduced replication origin licensing selectively kills KRAS-mutant colorectal cancer cells via mitotic catastrophe DISSERTATION zur Erlangung des akademischen Grades Doctor rerum naturalium (Dr. rer. nat.) eingereicht an der Lebenswissenschaftlichen View as HTML;KRAS OriGene TA801672 1:2,000 MCM2 BD 610701 1:2,000 1:50 pMCM2 Abcam ab133243 1:1,000 MCM7 Santa Cruz sc-9966 1:200
WB
Showing 1-6 of 6 papers.
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