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MDM2 Mouse Monoclonal Antibody [Clone ID: OTI4B3]

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SKU
TA801588
MDM2 mouse monoclonal antibody, clone OTI4B3 (formerly 4B3)
Size:
100 ul
Conjugation:
Unconjugated
  $447.00
In Stock*
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Frequently Bought Together (2)

TA811000S beta Actin Mouse Monoclonal Antibody, Clone OTI1, Loading Control 30 ul
$200.00
LY400855 Transient overexpression lysate of Mdm2 p53 binding protein homolog (mouse) (MDM2), transcript variant MDM2 (as WB positive control) 100 ug
$665.00

View other "MDM2 or NM_002392" antibodies

Specifications
Specifications
Product Data
Clone Name OTI4B3
Application WB
Recommended Dilution WB 1:2000
Reactivity Human
Antibody Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Human recombinant protein fragment corresponding to amino acids 119-438 of human MDM2 (NP_002383)produced in E.coli.
Buffer PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide
Concentration 1 mg/ml
Purification Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Shipping Blue Ice
Predicted Protein Size 55.8 kDa
Gene Name MDM2 proto-oncogene
Database Link
Background This gene is a target gene of the transcription factor tumor protein p53. The encoded protein is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53, as part of an autoregulatory negative feedback loop. Overexpression of this gene can result in excessive inactivation of tumor protein p53, diminishing its tumor suppressor function. This protein has E3 ubiquitin ligase activity, which targets tumor protein p53 for proteasomal degradation. This protein also affects the cell cycle, apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5. More than 40 different alternatively spliced transcript variants have been isolated from both tumor and normal tissues. provided by RefSeq, Jul 2008
Synonyms ACTFS; hdm2; HDMX
Reference Data
Protein Categories Cancer: Brain and CNS, Cancer: Gynecologic, Cancer: Sarcoma, Intracellular Proteins
Protein Families Druggable Genome, Transcription Factors
Protein Pathways Bladder cancer, Cell cycle, Chronic myeloid leukemia, Endocytosis, Glioma, Melanoma, p53 signaling pathway, Pathways in cancer, Prostate cancer, Ubiquitin mediated proteolysis
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Documents
Resources

file-alt Citations

Pathological prognostic factors of retroperitoneal liposarcoma: comprehensive clinicopathological analysis of 124 cases
Sun, Ma, Liu et al
Ann Transl Med (2021) 9 (7), 574 DOI: 10.21037/atm-21-972
Cited by 23
AI Summary: In this study, OriGene products, specifically the anti-Ki-67 antibody (TA500439) and anti-P53 antibody (TA802727), were used for immunohistochemical analysis to evaluate the expression of Ki-67 and P53 proteins as prognostic markers in retroperitoneal liposarcoma specimens.
FigureFigureFigure
Showing 1-1 of 1 papers.
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