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Hsp60 (HSPD1) Mouse Monoclonal Antibody [Clone ID: OTI3A2]

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SKU
TA800758S
HSPD1 mouse monoclonal antibody,clone OTI3A2
Size:
30 ul 100 ul
Conjugation:
Unconjugated
  $200.00
2 Days*
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Frequently Bought Together (2)

TA811000S beta Actin Mouse Monoclonal Antibody, Clone OTI1, Loading Control 30 ul
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LY400783 Transient overexpression lysate of heat shock 60kDa protein 1 (chaperonin) (HSPD1), nuclear gene encoding mitochondrial protein, transcript variant 1 (as WB positive control) 100 ug
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View other "Hsp60 or NM_199440" antibodies

Specifications
Specifications
Product Data
Clone Name OTI3A2
Application IHC, WB
Recommended Dilution WB 1:2000, IHC 1:150
Reactivity Dog, Human, Monkey, Mouse, Rat
Antibody Host Mouse
Isotype IgG2a
Clonality Monoclonal
Immunogen Full length human recombinant protein of human HSPD1 (NP_955472) produced in E.coli.
Buffer PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide
Concentration 1 mg/ml
Purification Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Shipping Blue Ice
Predicted Protein Size 60.9 kDa
Gene Name heat shock protein family D (Hsp60) member 1
Database Link
Background This gene encodes a member of the chaperonin family. The encoded mitochondrial protein may function as a signaling molecule in the innate immune system. This protein is essential for the folding and assembly of newly imported proteins in the mitochondria. This gene is adjacent to a related family member and the region between the 2 genes functions as a bidirectional promoter. Several pseudogenes have been associated with this gene. Two transcript variants encoding the same protein have been identified for this gene. Mutations associated with this gene cause autosomal recessive spastic paraplegia 13. [provided by RefSeq, Jun
Synonyms CPN60; GROEL; HLD4; HSP-60; HSP60; HSP65; HuCHA60; SPG13
Reference Data
Protein Categories Intracellular Proteins, Nervous system Diseases
Protein Families Druggable Genome, Stem cell - Pluripotency
Protein Pathways RNA degradation, Type I diabetes mellitus
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Other "OTI3A2" antibodies (4)
SKU Description Size Price
CF800758 Carrier-free (BSA/glycerol-free) HSPD1 mouse monoclonal antibody,clone OTI3A2 100 ug
$620.00
TA800758 HSPD1 mouse monoclonal antibody,clone OTI3A2 100 ul
$447.00
TA800758AM HSPD1 mouse monoclonal antibody,clone 3A2, Biotinylated 100 ul
$509.00
TA800758BM HSPD1 mouse monoclonal antibody,clone 3A2, HRP conjugated 100 ul
$509.00

file-alt Citations

Identification of the mitochondrial HSPD1 as metabolic vulnerability in non-small cell lung cancer
Parma
Thesis (2023)
Snippet: Background and aims: Cancer is a widespread disease characterized by uncontrollable cell proliferation and spread of metastasis. Lung cancer is the second most Save;Anti-β-Actin (8H10D10) HRP conjugate 12262 Cell signalling 1:10000 (WB) Mouse Anti-HSP60 (HSPD1), clone OTI3A2 TA800758 OriGene 1:100 (IHC) Mouse Anti-TOMM20 H00009804-M01 Abnova 1:1000 (WB)
WB IHC
Metabolic impairment of non-small cell lung cancers by mitochondrial HSPD1 targeting
Parma, Ramesh, Gollavilli et al
J Exp Clin Cancer Res (2021) 40 (1), 248 DOI: 10.1186/s13046-021-02049-8
Cited by 46
AI Summary: OriGene’s HSP60 (HSPD1) antibody (AbTA800758, Clone OTI3A2) was used to detect HSPD1 expression in NSCLC tissue samples by immunohistochemistry, contributing to the study’s analysis of HSPD1 as a potential therapeutic target.
Snippet: Briefly, samples were pre-treated for 36 min with antigen retrieval ULTRA CC1 then they were incubated for 32 min at 36 °C with HSP60 (HSPD1) (AbTA800758, Clone OTI3A2, 1:100 dilution, ORIGENE, Rockville, US) primary antibody. Immunofluorescence Cached
FigureFigureFigure
IHC IF
Impact of Lignocellulose Pretreatment By-Products on S. cerevisiae Strain Ethanol Red Metabolism during Aerobic and An-aerobic Growth
Kłosowski, Mikulski
Molecules (2021) 26 (4) DOI: 10.3390/molecules26040806
Cited by 37
AI Summary: OriGene's Hsp60 antibody was used in this study to detect and measure the yeast stress protein Hsp60, helping to assess Saccharomyces cerevisiae's cellular response to toxic by-products from lignocellulose pretreatment.
Snippet: Dilutions were selected according to the manufacturer’s protocol (Anti-Hsp31p-Host: goat, NSJ Bioreagents, San Diego, CA, USA;Hsp60 Antibody—Host: mouse, OriGene, Rockville, Maryland, USA)
FigureFigureFigure
Showing 1-3 of 3 papers.
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