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ALK Mouse Monoclonal Antibody [Clone ID: OTI1F1]

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SKU
TA800701
ALK mouse monoclonal antibody, clone OTI1F1 (formerly 1F1)
Size:
100 ul 30 ul
Formulation:
Standard Carrier-free
Conjugation:
Unconjugated Biotin HRP
  $447.00
In Stock*
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View other "ALK or NM_004304" antibodies

Specifications
Specifications
Product Data
Clone Name OTI1F1
Application LMNX
Recommended Dilution LMNX
Reactivity Human, Mouse, Rat
Antibody Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Human recombinant protein fragment corresponding to amino acids 1060-1620 of human ALK (NP_004295) produced in SF9 cell.
Buffer PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide
Concentration 1 mg/ml
Purification Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Shipping Blue Ice
Predicted Protein Size 176.3 kDa
Gene Name anaplastic lymphoma receptor tyrosine kinase
Database Link
Background This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X). provided by RefSeq, Jan 2011
Synonyms CD246; NBLST3
Reference Data
Protein Categories Cancer: Brain and CNS, Cancer: Haematopoietic and Lymphoid, Cancer: Lung, CD Markers, Enzyme: Kinases, Intracellular Proteins, Membrane Proteins
Protein Families Druggable Genome, Protein Kinase
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Other "OTI1F1" antibodies (4)
SKU Description Size Price
CF800701 Carrier-free (BSA/glycerol-free) ALK mouse monoclonal antibody, clone OTI1F1 (formerly 1F1) 100 ug
$620.00
TA800701AM ALK mouse monoclonal antibody,clone 1F1, Biotinylated 100 ul
$509.00
TA800701BM ALK mouse monoclonal antibody,clone 1F1, HRP conjugated 100 ul
$509.00
TA800701S ALK mouse monoclonal antibody, clone OTI1F1 (formerly 1F1) 30 ul
$200.00

file-alt Citations

The prevalence of tumour markers in malignant pleural effusions associated with primary pulmonary adenocarcinoma: a retrospective study
Fjaellegaard, Koefod Petersen, Andersen et al
Eur Clin Respir J (2021) 8 (1), 1984375 DOI: 10.1080/20018525.2021.1984375
Cited by 3
AI Summary: In this study, OriGene products—specifically, the anti-ALK antibody (OriGene, TA806214) and anti-PD-L1 antibody (OriGene, TA592595)—were used for immunohistochemical detection of ALK and PD-L1 tumour markers in pleural fluid specimens from patients with primary pulmonary adenocarcinoma.
Figure
Primary splenic B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and classical Hodgkin lymphoma: A case report
Shi, Zhou, Gao et al
Oncol Lett (2016) 12 (3), 1925-1928 DOI: 10.3892/ol.2016.4840
Cited by 5
AI Summary: OriGene’s EBV kit (catalogue number ISH-5021) was used to assess the presence of Epstein-Barr virus in tumor cells, confirming a negative result in this case report.
Snippet: These tumor cells demonstrated a negative reaction in the Epstein-Barr virus (EBV)-encoded small RNA assay (EBV kit;catalogue number ISH-5021;OriGene Technologies, Inc., Rockville, MD, USA)
Showing 1-2 of 2 papers.
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