XBP1 Rabbit Monoclonal Antibody [Clone ID: OTIR10G1]
Specifications
| Product Data | |
| Clone Name | OTIR10G1 |
|---|---|
| Application | WB |
| Recommended Dilution | WB1:2000 |
| Reactivity | Human, Mouse |
| Antibody Host | Rabbit |
| Isotype | IgG |
| Clonality | Monoclonal |
| Immunogen | Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) within Human XBP1 (NP_005071) . The exact sequence is proprietary. |
| Buffer | PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide |
| Concentration | 1 mg/ml |
| Purification | Purified from cell culture supernatant by affinity chromatography (protein A/G) |
| Conjugation | Unconjugated |
| Storage | Shipped at -20°C or with ice packs, Upon delivery store at -20°C. Dilute in PBS(pH7.3) if necessary. Stable for 12 months from date of receipt. Avoid repeated freeze-thaws. |
| Shipping | Blue Ice |
| Predicted Protein Size | 28.7KD |
| Gene Name | X-box binding protein 1 |
| Database Link | |
| Background | This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5. provided by RefSeq, Jul 2008 |
| Synonyms | TREB-5; TREB5; XBP-1; XBP2 |
| Reference Data | |
| Protein Families | Transcription Factors |
Reviews
Documents
| Product Manuals |
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Citations
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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