Methylmalonyl Coenzyme A mutase (MUT) Mouse Monoclonal Antibody [Clone ID: OTI2C8]
$447.00
In Stock*
Specifications
| Product Data | |
| Clone Name | OTI2C8 |
|---|---|
| Application | IF, WB |
| Recommended Dilution | WB 1:4000, IF 1:100 |
| Reactivity | Human, Mouse, Rat |
| Antibody Host | Mouse |
| Isotype | IgG2a |
| Clonality | Monoclonal |
| Immunogen | Full length human recombinant protein of human MUT(NP_000246) produced in HEK293T cell. |
| Buffer | PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide |
| Concentration | 1 mg/ml |
| Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Predicted Protein Size | 79.3 kDa |
| Gene Name | methylmalonyl-CoA mutase |
| Database Link | |
| Background | This gene encodes the mitochondrial enzyme methylmalonyl Coenzyme A mutase. In humans, the product of this gene is a vitamin B12-dependent enzyme which catalyzes the isomerization of methylmalonyl-CoA to succinyl-CoA, while in other species this enzyme may have different functions. Mutations in this gene may lead to various types of methylmalonic aciduria. provided by RefSeq, Jul 2008 |
| Synonyms | MCM |
| Reference Data | |
| Protein Categories | Intracellular Proteins |
| Protein Families | Druggable Genome |
| Protein Pathways | leucine and isoleucine degradation, Metabolic pathways, Propanoate metabolism, Valine |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other "OTI2C8" antibodies (4)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| CF506873 | Carrier-free (BSA/glycerol-free) MUT mouse monoclonal antibody, clone OTI2C8 (formerly 2C8) | 100 ug |
$620.00
|
|
| TA506873AM | MUT mouse monoclonal antibody,clone 2C8, Biotinylated | 100 ul |
$509.00
|
|
| TA506873BM | MUT mouse monoclonal antibody,clone 2C8, HRP conjugated | 100 ul |
$509.00
|
|
| TA506873S | MUT mouse monoclonal antibody, clone OTI2C8 (formerly 2C8) | 30 ul |
$200.00
|
|
Citations
Improved therapeutic efficacy in two mouse models of methylmalonic acidemia (MMA) using a second-generation mRNA therapy
Coughlan, Eybye, Henderson et al
Mol Genet Metab (2024) 143 (1-2), 108560 DOI: 10.1016/j.ymgme.2024.108560
Coughlan, Eybye, Henderson et al
Mol Genet Metab (2024) 143 (1-2), 108560 DOI: 10.1016/j.ymgme.2024.108560
Cited by 24
AI Summary: OriGene’s anti-MUT antibody (TA506873) was used to detect and quantify MMUT protein levels in mouse liver samples, enabling assessment of therapeutic efficacy in the study.
Snippet: Lysates (0.12 μg total protein per sample) were separated by capillary electrophoresis and probed with anti-MUT (TA506873, OriGene Technologies, Inc., Rockville, MD) and anti-Citrate synthetase (ab96600, Abcam, Cambridge, MA) antibodies to quantify the protein of interest and loading control protein, respectively
Showing 1-1 of 1 papers.
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