IL1 beta (IL1B) Mouse Monoclonal Antibody [Clone ID: OTI3E1]
$200.00
In Stock*
Specifications
| Product Data | |
| Clone Name | OTI3E1 |
|---|---|
| Application | IF, IHC, WB |
| Recommended Dilution | WB 1:1000~4000, IHC 1:150, IF 1:100 |
| Reactivity | Human |
| Antibody Host | Mouse |
| Isotype | IgG1 |
| Clonality | Monoclonal |
| Immunogen | Full length human recombinant protein of human IL1B(NP_000567) produced in HEK293T cell. |
| Buffer | PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide |
| Concentration | 1 mg/ml |
| Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Predicted Protein Size | 30.6 kDa |
| Gene Name | interleukin 1 beta |
| Database Link | |
| Background | The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. provided by RefSeq, Jul 2008 |
| Synonyms | IL-1; IL1-BETA; IL1F2 |
| Reference Data | |
| Protein Categories | Allergies and autoimmune diseases, Chemokines, Cytokines, Growth Factors, Intracellular Proteins, Secreated Proteins |
| Protein Families | Druggable Genome, Secreted Protein |
| Protein Pathways | Alzheimer's disease, Apoptosis, Cytokine-cytokine receptor interaction, Cytosolic DNA-sensing pathway, Graft-versus-host disease, Hematopoietic cell lineage, MAPK signaling pathway, NOD-like receptor signaling pathway, Prion diseases, Toll-like receptor signaling pathway, Type I diabetes mellitus |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other "OTI3E1" antibodies (4)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| CF506443 | Carrier-free (BSA/glycerol-free) IL1B mouse monoclonal antibody, clone OTI3E1 (formerly 3E1) | 100 ug |
$620.00
|
|
| TA506443 | IL1B mouse monoclonal antibody, clone OTI3E1 (formerly 3E1) | 100 ul |
$447.00
|
|
| TA506443AM | IL1B mouse monoclonal antibody,clone 3E1, Biotinylated | 100 ul |
$509.00
|
|
| TA506443BM | IL1B mouse monoclonal antibody,clone 3E1, HRP conjugated | 100 ul |
$509.00
|
|
Citations
IL-1beta expressing neutrophil extracellular traps in Legionella pneumophila infection
Koutantou, Konstantinidis, Chochlakis et al
Front Immunol (2025) 16, 1573151 DOI: 10.3389/fimmu.2025.1573151
Koutantou, Konstantinidis, Chochlakis et al
Front Immunol (2025) 16, 1573151 DOI: 10.3389/fimmu.2025.1573151
Cited by 3
AI Summary: In this study, the mouse anti-IL-1β antibody from OriGene was used to detect IL-1β on neutrophil extracellular traps, helping to elucidate the role of IL-1β in immune responses during Legionella pneumophila infection.
Snippet: anti-citrullinated H3 (R2+R8+R17) (1/500 dilution;Abcam) polyclonal Ab, a goat anti-myeloperoxidase (MPO)-specific mAb (1/150 dilution;R&D systems) and a mouse anti-IL-1β antibody (1/200 dilution;OriGene). A donkey anti-goat IgG (H+L) antibody conjugated to a fluorophore with an emission peak at 647 nm (1/500;Biotium), a donkey anti-rabbit IgG (H+L) antibody conjugated to a fluorophore with a
Gαq-PKD/PKCμ signal regulating the nuclear export of HDAC5 to induce the IκB expression and limit the NF-κB-mediated inflammatory response essential for early pregnancy
Jiang, He, Liu et al
Elife (2023) 12 DOI: 10.7554/eLife.83083
Jiang, He, Liu et al
Elife (2023) 12 DOI: 10.7554/eLife.83083
AI Summary: OriGene’s mouse monoclonal antibody against IL-1β (Cat# TA506443) was used in this study to detect IL-1β protein levels, contributing to the analysis of inflammatory responses during decidualization.
Snippet: d in 5% skimmed milk (BD) and probed with rabbit polyclonal antibody against Gαq, rabbit monoclonal antibody against IGFBP-1 (Abcam, Cat# ab181141, 1:1000), mouse monoclonal antibody against IL-1β (Origene Inc, Cat# TA506443, 1:1000), rabbit polyclonal antibody against p65 (Abcam, Cat# ab32536, 1:1000), rabbit polyclonal antibody against p50 (Abcam Cat# ab32360, 1:1000), p-STAT3 (Abcam Cat# ab76
Neutrophil extracellular traps in giant cell arteritis biopsies: presentation, localization and co-expression with inflammatory cytokines
Palamidas, Argyropoulou, Georgantzoglou et al
Rheumatology (Oxford) (2021)
Palamidas, Argyropoulou, Georgantzoglou et al
Rheumatology (Oxford) (2021)
Cited by 33
AI Summary: OriGene products contributed to this study by providing mouse monoclonal antibodies against IL-1β (TA506443), IL-6 (TA500067), and IL-17A (TA318811), which were used for immunodetection of these cytokines in tissue samples to assess their co-localization with neutrophil extracellular traps in giant cell arteritis biopsies.
Influence of hyperocclusion on the remodeling of gingival tissues
Li, Wang, Liu et al
Int Immunopharmacol (2021) 98, 107885 DOI: 10.1016/j.intimp.2021.107885
Li, Wang, Liu et al
Int Immunopharmacol (2021) 98, 107885 DOI: 10.1016/j.intimp.2021.107885
AI Summary: OriGene products contributed primary antibodies for proliferating cell nuclear antigen (PCNA), p65, interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), and β-catenin, which were used for immunohistochemical detection of key proteins involved in gingival tissue remodeling in this study.
Treponema pallidum promotes macrophage polarization and activates the NLRP3 inflammasome pathway to induce interleukin-1β production
Lin, Liu, Zhu et al
BMC Immunol. (2018) 19 (1), 28 DOI: 10.1186/s12865-018-0265-9
Lin, Liu, Zhu et al
BMC Immunol. (2018) 19 (1), 28 DOI: 10.1186/s12865-018-0265-9
AI Summary: In this study, OriGene’s anti-IL-1β antibody was used to detect IL-1β protein levels in macrophages, helping to demonstrate the role of NLRP3 inflammasome activation in response to Treponema pallidum infection.
Snippet: DF membrane for 1 h at 4 °C and 400 mA. After blocking with 5% milk and TBST, the membranes were incubated overnight at 4 °C with the following primary antibodies: anti-IL-1β (1:2000 dilution;Origene Inc., USA), anti-NLRP3 (1:1000 dilution;Abcam Inc., USA), anti-caspase-1 (active caspase-1(P20), 1:2000 dilution;R&D Systems Inc., USA) or anti-β-actin (1:5000 dilution;Abcam Inc., USA). T;... DF memb...
Duhuo Jisheng Decoction inhibits SDF-1-induced inflammation and matrix degradation in human degenerative nucleus pulposus cells in vitro through the CXCR4/NF-κB pathway
Liu, Wang, Huang et al
Acta Pharmacol. Sin. (2018) 39 (6), 912-922 DOI: 10.1038/aps.2018.36
Liu, Wang, Huang et al
Acta Pharmacol. Sin. (2018) 39 (6), 912-922 DOI: 10.1038/aps.2018.36
AI Summary: In this study, the OriGene mouse anti-TNF-α antibody was used to detect TNF-α protein levels, helping to assess the inflammatory response in human degenerative nucleus pulposus cells treated with Duhuo Jisheng Decoction.
Snippet: with primary antibodies rabbit anti-p-p65 and anti-p65 (Cell Signaling Technology, Inc, Beverly, MA, USA), rabbit anti-MMP-3 and anti-MMP-13 (Epitomics), rabbit anti-CXCR4 (Cell Signaling Technology, Inc, Beverly, MA, USA), mouse anti-TNF-α (OriGene, Herford
Showing 1-6 of 8 papers.
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