COPS6 Mouse Monoclonal Antibody [Clone ID: OTI4E7]
$200.00
In Stock*
Specifications
| Product Data | |
| Clone Name | OTI4E7 |
|---|---|
| Application | IF, IHC, WB |
| Recommended Dilution | WB 1:2000, IHC 1:150, IF 1:100 |
| Reactivity | Human, Mouse, Rat |
| Antibody Host | Mouse |
| Isotype | IgG2a |
| Clonality | Monoclonal |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 58-327 of human COPS6(NP_006824) produced in E.coli. |
| Buffer | PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide |
| Concentration | 1 mg/ml |
| Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Predicted Protein Size | 36 kDa |
| Gene Name | COP9 signalosome subunit 6 |
| Database Link | |
| Background | The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein belongs to translation initiation factor 3 (eIF3) superfamily. It is involved in the regulation of cell cycle and likely to be a cellular cofactor for HIV-1 accessory gene product Vpr. provided by RefSeq, Jul 2008 |
| Synonyms | CSN6; MOV34-34KD |
| Reference Data | |
| Protein Categories | Enzyme: Peptidases, Intracellular Proteins |
| Protein Families | Druggable Genome, Stem cell - Pluripotency |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other "OTI4E7" antibodies (4)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| CF505897 | Carrier-free (BSA/glycerol-free) COPS6 mouse monoclonal antibody, clone OTI4E7 (formerly 4E7) | 100 ug |
$620.00
|
|
| TA505897 | COPS6 mouse monoclonal antibody, clone OTI4E7 (formerly 4E7) | 100 ul |
$447.00
|
|
| TA505897AM | COPS6 mouse monoclonal antibody,clone 4E7, Biotinylated | 100 ul |
$509.00
|
|
| TA505897BM | COPS6 mouse monoclonal antibody,clone 4E7, HRP conjugated | 100 ul |
$509.00
|
|
Citations
EGFR-ERK pathway regulates CSN6 to contribute to PD-L1 expression in glioblastoma
Su, Guo, Lou et al
Mol. Carcinog. (2020)
Su, Guo, Lou et al
Mol. Carcinog. (2020)
Cited by 60
AI Summary: OriGene’s mouse anti-CSN6 antibody (cat. no. TA505897) was used in this study to detect CSN6 protein levels, enabling the investigation of its role in EGFR-ERK pathway-mediated regulation of PD-L1 expression in glioblastoma cells.
Snippet: 2.1 Materials. Rabbit anti‐EGF receptor, Rabbit anti‐p‐ERK, and Rabbit anti‐p‐EGFR were purchased from Cell Signaling (Danvers, MA). Mouse anti‐CSN6 antibody (cat. no. TA505897) was purchased from ORIGENE (Rockville, MD). Rabbit anti‐ PD‐L1 antibody
CSN6 expression is associated with pancreatic cancer progression and predicts poor prognosis
Shi, Guan, Zhan et al
Cancer Biol. Ther. (2019)
Shi, Guan, Zhan et al
Cancer Biol. Ther. (2019)
AI Summary: OriGene’s anti-CSN6 antibody was used for immunohistochemistry to detect and analyze CSN6 expression levels in pancreatic cancer and adjacent tissues, enabling the study’s findings on CSN6’s role in cancer progression and prognosis.
Snippet: The expression of CSN6 in PDAC tissues and adjacent noncancerous tissues was detected using immunohistochemistry (IHC). The pancreatic cancer tissues were cut into 4-μm-thick sections using a microtome, fixed on a glass slide, and deparaffinized. The slides were then heated in citrate buffer, incubated with 0.3% H2O2 for 10 minutes, and gradually hydrated with a gradient alcohol series. The slides...
Showing 1-2 of 2 papers.
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