SOCS3 Mouse Monoclonal Antibody [Clone ID: OTI3D3]
$447.00
In Stock*
Specifications
| Product Data | |
| Clone Name | OTI3D3 |
|---|---|
| Application | FC, IF, IHC, WB |
| Recommended Dilution | WB 1:2000, IHC 1:150, IF 1:100, FLOW 1:100 |
| Reactivity | Human, Mouse, Rat |
| Antibody Host | Mouse |
| Isotype | IgG2a |
| Clonality | Monoclonal |
| Immunogen | Full length human recombinant protein of human SOCS3 (NP_003946) produced in HEK293T cell. |
| Buffer | PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide |
| Concentration | 1 mg/ml |
| Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Predicted Protein Size | 24.6 kDa |
| Gene Name | suppressor of cytokine signaling 3 |
| Database Link | |
| Background | This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development. provided by RefSeq |
| Synonyms | ATOD4; CIS3; Cish3; SOCS-3; SSI-3; SSI3 |
| Note | WB application:Only overexpression results are guaranteed, not endogenous |
| Reference Data | |
| Protein Categories | Cytokines, Intracellular Proteins |
| Protein Families | Druggable Genome |
| Protein Pathways | Adipocytokine signaling pathway, Insulin signaling pathway, Jak-STAT signaling pathway, Type II diabetes mellitus, Ubiquitin mediated proteolysis |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other "OTI3D3" antibodies (4)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| CF502991 | Carrier-free (BSA/glycerol-free) SOCS3 mouse monoclonal antibody, clone OTI3D3 (formerly 3D3) | 100 ug |
$620.00
|
|
| TA502991AM | SOCS3 mouse monoclonal antibody, clone OTI3D3 (formerly 3D3), Biotinylated | 100 ul |
$509.00
|
|
| TA502991BM | SOCS3 mouse monoclonal antibody, clone OTI3D3 (formerly 3D3), HRP conjugated | 100 ul |
$509.00
|
|
| TA502991S | SOCS3 mouse monoclonal antibody, clone OTI3D3 (formerly 3D3) | 30 ul |
$200.00
|
|
Citations
Association Between Circulating CD4+ T Cell Methylation Signatures of Network-Oriented SOCS3 Gene and Hemodynamics in Patients Suffering Pulmonary Arterial Hypertension
Benincasa, Maron, Affinito et al
J Cardiovasc Transl Res (2022) 16 (1), 17-30 DOI: 10.1007/s12265-022-10294-1
Benincasa, Maron, Affinito et al
J Cardiovasc Transl Res (2022) 16 (1), 17-30 DOI: 10.1007/s12265-022-10294-1
Cited by 44
AI Summary: OriGene’s mouse anti-human anti-SOCS3 antibody (#TA502991) was used for Western blot analysis to confirm the upregulation of SOCS3 protein in peripheral blood mononuclear cells from pulmonary arterial hypertension patients compared to controls in this study.
Snippet: …The membranes were incubated with both mouse anti-human anti-SOCS3 (OriGene, #TA502991) at a dilution 1:1000 and mouse anti-human anti-GAPDH at a dilution 1:5000 (Santa-Cruz #sc-365062) overnight at 4 °C and next incubated with peroxidase-labeled secondary antibody;The membranes were incubated with both mouse anti-human anti-SOCS3 (OriGene, #TA502991) at a dilution 1:1000 and mouse anti-human anti-GAPDH at a dilution 1:5000 (Santa-Cruz #sc-365062) overnight at 4 °C and next incubated with peroxidase-labeled secondary antibody and visuali
Impact of PTEN/SOCS3 deletion on amelioration of dendritic shrinkage of retinal ganglion cells after optic nerve injury
Mak, Ng, Ren et al
Exp. Eye Res. (2020) 192, 107938 DOI: 10.1016/j.exer.2020.107938
Mak, Ng, Ren et al
Exp. Eye Res. (2020) 192, 107938 DOI: 10.1016/j.exer.2020.107938
Cited by 32
AI Summary: OriGene’s mouse anti-SOCS3 antibody was used in this study to detect SOCS3 protein levels, helping to assess the effects of PTEN/SOCS3 deletion on retinal ganglion cell structure after optic nerve injury.
Snippet: … The primary antibodies used were as follows: rabbit anti-PTEN (Cell Signaling Technology), mouse anti-SOCS3 (Origene), rabbit anti-TUJ1 (Biolegend), mouse anti-TUJ1 (Biolegend), and mouse anti-SMI-32 (Biolegend);saline. The primary antibodies used were as follows: rabbit anti-PTEN (Cell Signaling Technology), mouse anti-SOCS3 (Origene), rabbit anti-TUJ1(Biolegend), mouse anti-TUJ1 (Biolegend), and mouse anti-SMI-32 (Biolegend);- saline. The primary antibodies used were as follows: rabbit anti-PTEN (Cell Signaling Technology), mouse anti-SOCS3 (Origene), rabbit anti-TUJ1(Biolegend), mouse anti-TUJ1 (Biolegend), and mouse anti-SMI-32 (Biolegend)
Glycosylation-dependent interaction between CD69 and S100A8/S100A9 complex is required for regulatory T-cell differentiation
Lin, Wei, Tsai et al
FASEB J. (2015)
Lin, Wei, Tsai et al
FASEB J. (2015)
Cited by 74
Showing 1-3 of 3 papers.
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