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PAICS Mouse Monoclonal Antibody [Clone ID: OTI5B6]

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SKU
TA501469
Anti-PAICS mouse monoclonal antibody, clone OTI5B6 (formerly 5B6)
Size:
100 ul 30 ul
Formulation:
Standard Carrier-free
Conjugation:
Unconjugated Biotin HRP
  $447.00
In Stock*
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View other "PAICS or NM_006452" antibodies

Specifications
Specifications
Product Data
Clone Name OTI5B6
Application FC, IF, Simple Western, WB
Recommended Dilution WB 1:2000, IF 1:100, Flow: 1:100, Simple Western 1:20-1:50
Reactivity Human, Mouse, Rat
Antibody Host Mouse
Isotype IgG2b
Clonality Monoclonal
Immunogen Full length human recombinant protein of human PAICS (NP_006443) produced in HEK293T cell.
Buffer PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide
Concentration 1 mg/ml
Purification Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Shipping Blue Ice
Predicted Protein Size 46.9 kDa
Gene Name phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase
Database Link
Background This gene encodes a bifunctional enzyme containing phosphoribosylaminoimidazole carboxylase activity in its N-terminal region and phosphoribosylaminoimidazole succinocarboxamide synthetase in its C-terminal region. It catalyzes steps 6 and 7 of purine biosynthesis. The gene is closely linked and divergently transcribed with a locus that encodes an enzyme in the same pathway, and transcription of the two genes is coordinately regulated. The human genome contains several pseudogenes of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. provided by RefSeq
Synonyms ADE2; ADE2H1; AIRC; PAIS
Reference Data
Protein Categories Enzyme: Ligase, Intracellular Proteins
Protein Families Druggable Genome
Protein Pathways Metabolic pathways, Purine metabolism
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Other "OTI5B6" antibodies (4)
SKU Description Size Price
CF501469 Carrier-free (BSA/glycerol-free) PAICS mouse monoclonal antibody, clone OTI5B6 (formerly 5B6) 100 ug
$620.00
TA501469AM Anti-PAICS mouse monoclonal antibody, clone OTI5B6 (formerly 5B6), Biotinylated 100 ul
$509.00
TA501469BM Anti-PAICS mouse monoclonal antibody, clone OTI5B6 (formerly 5B6), HRP conjugated 100 ul
$509.00
TA501469S Anti-PAICS mouse monoclonal antibody, clone OTI5B6 (formerly 5B6) 30 ul
$200.00

file-alt Citations

PAICS deficiency, a new defect of de novo purine synthesis resulting in multiple congenital anomalies and fatal outcome
Pelet, Skopova, Steuerwald et al
Hum. Mol. Genet. (2019)
AI Summary: OriGene’s mouse monoclonal anti-PAICS antibody was used in this study to detect PAICS protein levels, contributing to the characterization of the enzyme deficiency in patient fibroblasts.
Snippet: a PVDF membrane. The membrane was blocked with 5% BSA in PBS-T (PBS with 0.05%Tween20) and probed with primary antibodies: mouse monoclonal anti-PAICS (Origene) and mouse monoclonal anti-GAPDH (Sigma
WB
CRISPR-Cas9 induced mutations along de novo purine synthesis in HeLa cells result in accumulation of individual enzyme substrates and affect purinosome formation
Baresova, Krijt, Skopova et al
Mol Genet Metab (2016) 119 (3), 270-277 DOI: 10.1016/j.ymgme.2016.08.004
Cited by 40
AI Summary: In this study, OriGene products—including the pCMV6-Entry vector and specific human DNPS enzyme cDNA clones—were used to generate recombinant DNPS enzymes for biochemical substrate preparation, enabling the development and validation of LC-MS/MS assays to analyze purine synthesis pathway disruptions in genome-edited HeLa cells.
Showing 1-2 of 2 papers.
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