Cytochrome P450 2E1 (CYP2E1) Mouse Monoclonal Antibody [Clone ID: OTI5B9]
SKU
TA500734
Anti-CYP2E1 (Cytochrome P450 2E1) mouse monoclonal antibody, clone OTI5B9 (formerly 5B9)
$447.00
In Stock*
Specifications
| Product Data | |
| Clone Name | OTI5B9 |
|---|---|
| Application | IF, IHC, WB |
| Recommended Dilution | WB 1:500, IHC 1:50, IF 1:100 |
| Reactivity | Human |
| Antibody Host | Mouse |
| Isotype | IgG1 |
| Clonality | Monoclonal |
| Immunogen | Full length human recombinant protein of human CYP2E1 (NP_000764) produced in HEK293T cell. |
| Buffer | PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide |
| Concentration | 0.53 mg/ml |
| Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Predicted Protein Size | 56.8 kDa |
| Gene Name | cytochrome P450 family 2 subfamily E member 1 |
| Database Link | |
| Background | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer. |
| Synonyms | CPE1; CYP2E; P450-J; P450C2E |
| Reference Data | |
| Protein Categories | Intracellular Proteins |
| Protein Families | Druggable Genome, P450, Transmembrane |
| Protein Pathways | Arachidonic acid metabolism, Drug metabolism - cytochrome P450, Linoleic acid metabolism, Metabolic pathways, Metabolism of xenobiotics by cytochrome P450 |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other "OTI5B9" antibodies (4)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| CF500734 | Carrier-free (BSA/glycerol-free) CYP2E1 mouse monoclonal antibody, clone OTI5B9 (formerly 5B9) | 100 ug |
$620.00
|
|
| TA500734AM | Anti-CYP2E1 (Cytochrome P450 2E1) mouse monoclonal antibody, clone OTI5B9 (formerly 5B9), Biotinylated | 100 ul |
$509.00
|
|
| TA500734BM | Anti-CYP2E1 (Cytochrome P450 2E1) mouse monoclonal antibody, clone OTI5B9 (formerly 5B9), HRP conjugated | 100 ul |
$509.00
|
|
| TA500734S | Anti-CYP2E1 (Cytochrome P450 2E1) mouse monoclonal antibody, clone OTI5B9 (formerly 5B9) | 30 ul |
$200.00
|
|
Citations
SUMOylation regulates cytochrome P450 2E1 expression and activity in alcoholic liver disease
Tomasi, Ramani, Ryoo et al
The FASEB Journal (2018) 32 (6), fj.201701124R DOI: 10.1096/fj.201701124R
Tomasi, Ramani, Ryoo et al
The FASEB Journal (2018) 32 (6), fj.201701124R DOI: 10.1096/fj.201701124R
AI Summary: OriGene’s anti-CYP2E1 antibody was used in this study to detect CYP2E1 protein levels by Western blotting, enabling the researchers to assess how SUMOylation regulates CYP2E1 expression and activity in alcoholic liver disease.
Snippet: Immunoprecipitated proteins were subjected to Western blotting following standard pro- tocols (Amersham BioSciences, Piscataway, NJ, USA), and the membranes were probed with the anti-CYP2E1 antibody (Origene, Rockville, MD, USA). The Clean-Blot IP Reagent
Showing 1-1 of 1 papers.
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