Glutamine Synthetase (GLUL) Mouse Monoclonal Antibody [Clone ID: OTI1F4]
$200.00
In Stock*
Specifications
| Product Data | |
| Clone Name | OTI1F4 |
|---|---|
| Application | FC, IF, IHC, WB |
| Recommended Dilution | WB 1:1000~2000, IHC 1:50, IF 1:50~100, FLOW 1:100 |
| Reactivity | Human, Mouse, Rat |
| Antibody Host | Mouse |
| Isotype | IgG2a |
| Clonality | Monoclonal |
| Immunogen | Full length human recombinant protein of human GLUL (NP_002056) produced in HEK293T cell. |
| Buffer | PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide |
| Concentration | 1 mg/ml |
| Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Predicted Protein Size | 41.9 kDa |
| Gene Name | glutamate-ammonia ligase |
| Database Link | |
| Background | The protein encoded by this gene belongs to the glutamine synthetase family. It catalyzes the synthesis of glutamine from glutamate and ammonia. Glutamine is a main source of energy and is involved in cell proliferation, inhibition of apoptosis, and cell signaling. This gene is expressed during early fetal stages, and plays an important role in controlling body pH by removing ammonia from circulation. Mutations in this gene are associated with congenital glutamine deficiency. Several alternatively spliced transcript variants have been found for this gene. |
| Synonyms | GLNS; GS; PIG43; PIG59 |
| Reference Data | |
| Protein Categories | Enzyme: Ligase, Intracellular Proteins |
| Protein Pathways | Alanine, Arginine and proline metabolism, aspartate and glutamate metabolism, Metabolic pathways, Nitrogen metabolism |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other "OTI1F4" antibodies (4)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| CF500700 | Carrier-free (BSA/glycerol-free) GLUL mouse monoclonal antibody, clone OTI1F4 (formerly 1F4) | 100 ug |
$620.00
|
|
| TA500700 | GLUL mouse monoclonal antibody, clone OTI1F4 (formerly 1F4) | 100 ul |
$447.00
|
|
| TA500700AM | GLUL mouse monoclonal antibody, clone OTI1F4 (formerly 1F4), Biotinylated | 100 ul |
$509.00
|
|
| TA500700BM | GLUL mouse monoclonal antibody, clone OTI1F4 (formerly 1F4), HRP conjugated | 100 ul |
$509.00
|
|
Citations
Functional editing of the OTC locus by targeted integration with phenotype correction and restoration of endogenous expression patterns
Ginn, Doroudian, Christina et al
Mol Ther (2026)
Ginn, Doroudian, Christina et al
Mol Ther (2026)
Cited by 1
AI Summary: OriGene’s anti-glutamine synthetase antibody (Cat # TA500700, clone OTI1F4) was used to assess restoration of liver metabolic zonation in tissue sections, supporting evaluation of the gene editing approach’s effectiveness.
Snippet: For C57BL/6J mice, sections were incubated with anti-GFP conjugated with DyLight 488 (Rockland Immunochemicals, Limerick, PA;Cat #600-141-215;1:800 dilution) at room temperature for 1 h and anti-glutamine synthetase (OriGene, Rockville, MD;Cat # TA500700 clone OTI1F4;1:100 dilution) for 1.5 h at room temperature, followed by a polyclonal donkey anti-mouse Alexa Fluor 594 (Invitrogen;Cat # A32744;1:800 dilution)
Characterization of the humanized FRG mouse model and development of an AAV-LK03 variant with improved liver lobular biodistribution
Cabanes-Creus, Navarro, Liao et al
Mol Ther Methods Clin Dev (2023) 28, 220-237 DOI: 10.1016/j.omtm.2022.12.014
Cabanes-Creus, Navarro, Liao et al
Mol Ther Methods Clin Dev (2023) 28, 220-237 DOI: 10.1016/j.omtm.2022.12.014
Cited by 21
AI Summary: OriGene’s anti-GS antibody (#TA500700) was used for immunofluorescence analyses to assess zone-dependent enzyme expression in human hepatocytes within the liver xenograft mouse model in this study.
Snippet: … When indicated in the figure legends, anti-GS (Origene;#TA500700) was used. For Figure 2 [/pmc/articles/PMC9860073/figure/fig2/]A, anti-HAL (Sigma Prestige Antibodies;#HPA038547), anti-ASL (Invitrogen;#PA5-22300), anti-ASS (Invitrogen;#PA5-82;#TA500700) was used. …
MYC regulates the unfolded protein response and glucose and glutamine uptake in endocrine resistant breast cancer
Shajahan-Haq, Cook, Schwartz-Roberts et al
Mol. Cancer (2014) 13, 239 DOI: 10.1186/1476-4598-13-239
Shajahan-Haq, Cook, Schwartz-Roberts et al
Mol. Cancer (2014) 13, 239 DOI: 10.1186/1476-4598-13-239
Cited by 87
AI Summary: In this study, the OriGene GLUL antibody was used to investigate the role of glutamine metabolism in endocrine resistant breast cancer cells, helping to demonstrate MYC's regulation of the unfolded protein response and nutrient uptake.
Snippet: GRP78, IRE1α, phospho-JNK(Thr183/ Tyr185), JNK, CHOP, cleaved Caspase-7 (CASP7), LC3B, (Cell Signaling, Danvers, MA);p62/SQSTM1 (BD Biosciences, San Jose, CA);GLS (Abnova, Taipei City, Taiwan;Abcam, Cambridge, England);GLUL (Origene, ... Cite SaveSaving
Showing 1-3 of 3 papers.
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