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HSP90AB1 Mouse Monoclonal Antibody [Clone ID: OTI4C10]

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SKU
TA500494
Mouse monoclonal anti-HSP90AB1(HSP90) antibody, clone 4C10, Load, clone OTI4C10 (formerly 4C10)
Size:
100 ul 30 ul
Formulation:
Standard Carrier-free
Conjugation:
Unconjugated HRP
  $447.00
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View other "HSP90AB1 or NM_007355" antibodies

Specifications
Specifications
Product Data
Clone Name OTI4C10
Application Simple Western, WB
Recommended Dilution WB 1:2000, Simple Western 1:20-1:50
Reactivity Dog, Human, Monkey, Mouse, Rat
Antibody Host Mouse
Isotype IgG2b
Clonality Monoclonal
Immunogen Full-length protein expressed in 293T cell transfected with human HSP90AB1 expression vector
Buffer PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide
Concentration 1 mg/ml
Purification Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Shipping Blue Ice
Predicted Protein Size 83.3 kDa
Gene Name heat shock protein 90 alpha family class B member 1
Database Link
Background HSP90 proteins are highly conserved molecular chaperones that have key roles in signal transduction, protein folding, protein degradation, and morphologic evolution. HSP90 proteins normally associate with other cochaperones and play important roles in folding newly synthesized proteins or stabilizing and refolding denatured proteins after stress. There are 2 major cytosolic HSP90 proteins, HSP90AA1 (MIM 140571), an inducible form, and HSP90AB1, a constitutive form. Other HSP90 proteins are found in endoplasmic reticulum (HSP90B1; MIM 191175) and mitochondria (TRAP1; MIM 606219)
Synonyms D6S182; HSP84; HSP90B; HSPC2; HSPCB
Reference Data
Protein Categories Growth Factors, Intracellular Proteins
Protein Families Druggable Genome, Stem cell - Pluripotency
Protein Pathways Antigen processing and presentation, NOD-like receptor signaling pathway, Pathways in cancer, Progesterone-mediated oocyte maturation, Prostate cancer
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Other "OTI4C10" antibodies (3)
SKU Description Size Price
CF500494 Carrier-free (BSA/glycerol-free) HSP90AB1 mouse monoclonal antibody, clone OTI4C10 (formerly 4C10) 100 ug
$620.00
TA500494BM HRP conjugated mouse monoclonal HSP90AB1 antibody 100 ul
$509.00
TA500494S Mouse monoclonal anti-HSP90AB1(HSP90) antibody, clone 4C10, Load, clone OTI4C10 (formerly 4C10) 30 ul
$200.00

file-alt Citations

Intestinal-specific ketohexokinase deficiency ameliorates high fructose-induced metabolic dysfunction across the intestinal-liver-kidney axis in mice
Song, Yi, Wang et al
J Nutr Biochem (2026)
AI Summary: In this study, the HSP90 antibody (Catalog #TA500494) from OriGene was used as a primary antibody in immunoblotting experiments to assess protein expression levels, contributing to the evaluation of metabolic changes in mice with intestinal-specific ketohexokinase deficiency.
Snippet: antibody dilution buffer (1.5 g BSA, 0.1 g NaN3, 50 ml TBST). Primary antibodies included: KHK-A (Catalog #21708, SAB Signalway, 1:1000);KHK-C (Catalog #21709, SAB Signalway, 1:1000);AQP2 (Catalog #A7310, Sigma, 1:2000);and HSP90 (Catalog #TA500494, OriGene, 1:10,000). …
Pax8-rtTA/LC1-Driven Inducible Ketohexokinase Deletion Protects Against High Fructose-Induced Metabolic Syndrome in Mice
Yi, Zhu, Wang et al
Acta Physiol (Oxf) (2026) 242 (4), e70187 DOI: 10.1111/apha.70187
Cited by 4
AI Summary: OriGene’s HSP90 antibody (TA500494) was used for immunoblotting to detect protein expression levels in the study investigating the effects of inducible ketohexokinase deletion on fructose-induced metabolic syndrome in mice.
Snippet: Cell Signaling Technology;HSP90, 1:10000 dilution, TA500494, OriGene] diluted in antibody dilution buffer (1.5 g BSA, 0.1 g NaN3, 50 mL TBST) overnight at 4°C. After being washed with TBST, membranes were incubated with secondary antibodies
CD59 promotes pancreatic cancer progression via a tumor cell-intrinsic JAK2-STAT3 signaling axis
Li, Chen, Wu et al
Biochem Biophys Res Commun (2026) 812, 153609 DOI: 10.1016/j.bbrc.2026.153609
AI Summary: OriGene’s HSP90 antibody (TA500494) was used in this study to assess protein expression levels, supporting the investigation of the molecular mechanisms by which CD59 promotes pancreatic cancer progression.
Snippet: phospho-STAT3 (Tyr705, 9145), phospho-JAK2 (Tyr1007/1008, 3776), and phospho-JAK1 (Tyr1034/1035, 74129) (Cell Signaling Technology), HSP90 (TA500494, Origene), and phospho-ERK (80031-1-RR), ERK1/2 (11257-1-AP), KRAS (12063-1-AP),
Tongue squamous cell carcinoma exosomal miR-122-5p promotes the conversion from fibroblasts to inflammatory cancer-associated fibroblasts
Xia, Wu, Zhang et al
Discov Oncol (2026)
AI Summary: OriGene's HSP90 antibody (#TA500494) was used in this study to detect HSP90 protein levels, contributing to the analysis of molecular changes during the conversion of fibroblasts to inflammatory cancer-associated fibroblasts in tongue squamous cell carcinoma.
Snippet: and IL-6 (#ab9324) were obtained from Abcam (Wales, UK). Antibodies against HSP90 (#TA500494) were sourced from OriGene Technologies (Rockville, USA). The antibodies against GAPDH
Targeting TRIM15-mediated Axin1 depolymerization suppresses Wnt signaling and inhibits colorectal cancer growth
Liang, Zheng, Wu et al
Cell Death Dis (2025)
Cited by 2
AI Summary: OriGene products, specifically antibodies against β-Tubulin (TA503129), GFP (TA150052), and HSP90 (TA500494), were used in this study to detect and analyze protein expression levels, supporting the investigation of TRIM15's role in Axin1 polymerization and Wnt signaling in colorectal cancer.
Snippet: Antibodies against β-Tubulin (TA503129), GFP (TA150052) and HSP90 (TA500494) were purchased from Origene
Tracking Chaperone-Mediated Autophagy Flux with a pH-Resistant Fluorescent Reporter
Qi, Chen, Li et al
International Journal of Molecular Sciences (2024) 26 (1), 17-17 DOI: 10.3390/ijms26010017
Cited by 2
AI Summary: OriGene's anti-HSP90 antibody (TA500494) was used in this study to detect HSP90 protein levels via immunoblotting, supporting the analysis of chaperone-mediated autophagy activity.
Snippet: TS The primary antibodies used in this study were as follows: mouse monoclonal anti-Halo (Promega, Madison, WI, USA, G9211, 1:1000), anti-LAMP2A (Abcam, Cambridge, UK, ab125068, 1:1000), anti-HSP90 (Origene, Rockville, MD, USA, TA500494, 1:1000), anti-β-actin (Santa Cruz, Dallas, TX, USA, sc-69879, 1:1000);rabbit polyclonal anti-VPS4 (Sigma, St. Louis, MA, USA, SAB4200025, 1:1000);and anti-RB1
WB
Showing 1-6 of 27 papers.
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