TRPM4 Mouse Monoclonal Antibody [Clone ID: OTI10H5]
Specifications
| Product Data | |
| Clone Name | OTI10H5 |
|---|---|
| Application | IHC, Simple Western, WB |
| Recommended Dilution | WB 1:500~2000, IHC 1:50; Simple Western 1:20-1:50 |
| Reactivity | Human |
| Antibody Host | Mouse |
| Isotype | IgG1 |
| Clonality | Monoclonal |
| Immunogen | Full length human recombinant protein of human TRPM4 (NP_060106) produced in HEK293T cell. |
| Buffer | PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide |
| Concentration | 1 mg/ml |
| Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Predicted Protein Size | 134.3 kDa |
| Gene Name | transient receptor potential cation channel subfamily M member 4 |
| Database Link | |
| Background | Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca(2+), it is impermeable to it. Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca(2+) overload. |
| Synonyms | hTRPM4; LTrpC4; PFHB1B; TRPM4B |
| Reference Data | |
| Protein Categories | Cardiovascular diseases, Cytokines, Intracellular Proteins, Membrane Proteins |
| Protein Families | Druggable Genome, Ion Channels: Transient receptor potential, Transmembrane |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other "OTI10H5" antibodies (4)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| CF500381 | Carrier-free (BSA/glycerol-free) TRPM4 mouse monoclonal antibody, clone OTI10H5 (formerly 10H5) | 100 ug |
$620.00
|
|
| TA500381AM | TRPM4 mouse monoclonal antibody, clone OTI10H5 (formerly 10H5), Biotinylated | 100 ul |
$509.00
|
|
| TA500381BM | TRPM4 mouse monoclonal antibody, clone OTI10H5 (formerly 10H5), HRP conjugated | 100 ul |
$509.00
|
|
| TA500381S | TRPM4 mouse monoclonal antibody, clone OTI10H5 (formerly 10H5) | 30 ul |
$200.00
|
|
Citations
Zhu, Dai, Ghosh et al
J Exp Clin Cancer Res (2025) 44 (1), 299 DOI: 10.1186/s13046-025-03559-5
Haferkamp, Telugu, Krieg et al
Stem Cell Res (2024) 81, 103609 DOI: 10.1016/j.scr.2024.103609
Mitsou, Carlson, Multhaupt et al
J Histochem Cytochem (2023) 71 (9), 221554231194119 DOI: 10.1369/00221554231194119
(Otsuka) Saito, Fujita, Toriyama et al
Biochemical and Biophysical Research Communications (2023) 654, 1-9 DOI: 10.1016/j.bbrc.2023.02.062
Verigos, Kordias, Papadaki et al
Biomedicines (2021) 9 (10) DOI: 10.3390/biomedicines9101368
Dienes, Hézső, Kiss et al
Int J Mol Sci (2021) 22 (17) DOI: 10.3390/ijms22179499
Related Products
- Price:
- Actual Price:
Welcome to OriGene AI!
I'm your AI-powered guide to everything OriGene.
Ask me anything:
- Product specs
- Ordering help
- Technical questions
- How to find exactly what your experiment needs
Prefer a live agent? Connect with us by clicking the green chat icon, as seen in the image below or email our team at custsupport@origene.com.