Periostin (POSTN) Mouse Monoclonal Antibody [Clone ID: OTI1A1]
$447.00
In Stock*
Specifications
| Product Data | |
| Clone Name | OTI1A1 |
|---|---|
| Application | IF, WB |
| Recommended Dilution | WB 1:500, IF 1:100 |
| Reactivity | Human, Mouse, Rat |
| Antibody Host | Mouse |
| Isotype | IgM |
| Clonality | Monoclonal |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1-230 of human periostin (NP_006466) produced in E.coli. |
| Buffer | PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide |
| Concentration | 1 mg/ml |
| Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Predicted Protein Size | 93.2 kDa |
| Gene Name | periostin |
| Database Link | |
| Background | Periostin is a disulfide linked 90 kDa, 811 amino acid protein originally isolated as a osteoblast-specific factor that functions as a cell adhesion molecule for preosteoblasts and is thought to be involved in osteoblast recruitment, attachment and spreading. Additionally, periostin expression has previously been shown to be significantly increased by both transforming growth factor beta 1(TGF beta 1) and bone morphogenetic protein (BMP2). Periostin mRNA is expressed in the developing mouse embryonic and fetal heart, and that it is localized to the endocardial cushions that ultimately divide the primitive heart tube into a four-chambered heart. Abnormal expression of periostin is also linked to angiogenesis and metastatsis in epithelial tumors. |
| Synonyms | OSF-2; OSF2; PDLPOSTN; PN |
| Reference Data | |
| Protein Categories | ADC Targets, Secreated Proteins |
| Protein Families | Druggable Genome, Secreted Protein |
Reviews
Documents
| Product Manuals |
| FAQs |
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Resources
Other "OTI1A1" antibodies (4)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| CF500070 | Carrier-free (BSA/glycerol-free) Periostin mouse monoclonal antibody, clone OTI1A1 (formerly 1A1) | 100 ug |
$620.00
|
|
| TA500070AM | Periostin mouse monoclonal antibody, clone 1A1, Biotinylated | 100 ul |
$509.00
|
|
| TA500070BM | Periostin mouse monoclonal antibody, clone 1A1, HRP conjugated | 100 ul |
$509.00
|
|
| TA500070S | Periostin (Periostin) mouse monoclonal antibody, clone OTI1A1 (formerly 1A1) | 30 ul |
$200.00
|
|
Citations
Novel technique for the simultaneous isolation of cardiac fibroblasts and epicardial stromal cells from the infarcted murine heart
Owenier, Hesse, Alter et al
Cardiovasc Res (2020) 116 (5), 1047-1058 DOI: 10.1093/cvr/cvz193
Owenier, Hesse, Alter et al
Cardiovasc Res (2020) 116 (5), 1047-1058 DOI: 10.1093/cvr/cvz193
Cited by 12
AI Summary: In this study, OriGene products—including the Wilms-tumor-protein-1 (anti-WT1 antibody) and qPCR primers—were used to confirm the purity and characterize gene expression profiles of isolated cardiac fibroblasts and epicardial stromal cells from infarcted mouse hearts.
MicroRNA-98-HMGA2-POSTN signal pathway reverses epithelial-to-mesenchymal transition in laryngeal squamous cell carcinoma
Zhu, Zhang, Chen et al
Biomed. Pharmacother. (2019) 117, 108998 DOI: 10.1016/j.biopha.2019.108998
Zhu, Zhang, Chen et al
Biomed. Pharmacother. (2019) 117, 108998 DOI: 10.1016/j.biopha.2019.108998
AI Summary: In this study, the OriGene POSTN (mouse anti-human mAb; #TA500070) antibody was used to detect POSTN protein expression, helping to elucidate the role of the miR-98-HMGA2-POSTN signaling pathway in reversing epithelial-to-mesenchymal transition in laryngeal squamous cell carcinoma.
Snippet: 3195), GAPDH (rabbit anti-human mAb;Cell Signaling Technology, #5174), HMGA2 (rabbit anti-human mAb;Cell Signaling Technology, #8179), TWIST (rabbit anti-human mAb;Cell Signaling Technology, #46,702), POSTN (mouse anti-human mAb;OriGene, #TA500070;
Periostin overexpression in collecting ducts accelerates renal cyst growth and fibrosis in polycystic kidney disease
Raman, Parnell, Zhang et al
Am. J. Physiol. Renal Physiol. (2018) 315 (6), F1695-F1707 DOI: 10.1152/ajprenal.00246.2018
Raman, Parnell, Zhang et al
Am. J. Physiol. Renal Physiol. (2018) 315 (6), F1695-F1707 DOI: 10.1152/ajprenal.00246.2018
AI Summary: In this study, the Periostin antibody (TA500070) from OriGene was used to detect periostin expression in kidney tissues, helping to demonstrate its role in accelerating cyst growth and fibrosis in polycystic kidney disease.
Snippet: one hour at room temperature. Antibodies that were used include: PCNA (AbCam [ab], 125 Boston, MA;ab29, Ki-67 (ab15880), periostin (Origene, Rockville, MD;TA500070), P- 126 S6 (Cell Signaling Technology [CS], Beverly, MA [CS]4858), collagen I (ab34710)
Tumor-associated macrophages recruited by periostin in intrahepatic cholangiocarcinoma stem cells
Zeng, Liu, Sun et al
Oncol Lett (2018) 15 (6), 8681-8686 DOI: 10.3892/ol.2018.8372
Zeng, Liu, Sun et al
Oncol Lett (2018) 15 (6), 8681-8686 DOI: 10.3892/ol.2018.8372
AI Summary: OriGene products, specifically the POSTN primary antibody (TA804575) and the secondary biotinylated mouse antibody (TA130008), were used in immunohistochemical analyses to detect periostin expression in tissue sections, contributing to the study's investigation of periostin's role in recruiting tumor-associated macrophages in intrahepatic cholangiocarcinoma.
Snippet: Immunohistochemical examination For immunohistochemical analysis of POSTN (TA804575;1:100;OriGene Technologies, Inc., Beijing, China) and CD206 (SC-376232;Santa Cruz Biotechnology, Inc., Dallas, TX, USA), tissue sections (thickness=4 mm) were deparaffinized in 100% xylene and rehydrated in graded concentrations (100, 95, 70 and 50%) of ethanol. Following incubation with 1% bovine serum albumin (BSA;Beijing Dingguo Changsheng Biotechnology Co., Ltd., Beijing, China) in PBS (pH 7.4) at 37°C for 30 min, the tissue sections were then incubated with primary antibody for 1 h at room temperature, followed by incubation with the secondary biotinylated mouse antibody (TA130008;OriGene Technologies, Inc., Beijing, China) at 37°C for 30 min. …
Hertwig's epithelial root sheath cells contribute to formation of periodontal ligament through epithelial-mesenchymal transition by TGF-β
Itaya, Oka, Ogata et al
Biomed. Res. (2017) 38 (1), 61-69 DOI: 10.2220/biomedres.38.61
Itaya, Oka, Ogata et al
Biomed. Res. (2017) 38 (1), 61-69 DOI: 10.2220/biomedres.38.61
AI Summary: OriGene Technologies contributed to this study by providing the rabbit anti-N-cadherin antibody, which was used in immunoblotting experiments to assess changes in cadherin expression during TGF-β-induced epithelial-mesenchymal transition in HERS cells.
Snippet: The membranes were immunoblotted separately with mouse anti-β-actin (Santa Cruz Bio- technology Inc., Dallas, TX), mouse anti-E-cadherin (BD Biosciences, San Jose, CA), rabbit anti-N-cad- herin (OriGene Technologies Inc., Rockville, MD), rabbit anti-fibronectin ... Cite SaveSaving
Showing 1-5 of 5 papers.
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