Neurotrophin 4(NTF4) Mouse Monoclonal Antibody [Clone ID: OTI2E8]
NT4 (Neurotrophin 4) mouse monoclonal antibody, clone OTI2E8 (formerly 2E8)
Product Datasheet for 'TA500034'
|Applications||WB, IHC, IF|
|Recommend Dilution||WB 1:5000, IHC 1:50, IF 1:50,|
|Immunogen||Human recombinant protein fragment corresponding to amino acids 81-210 human NT4 (NP_006170) produced in E.coli.|
|Formulation||PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.|
|Purification||Purified from mouse ascites fluids by affinity chromatography|
|Predicted Protein Size||22.2 kDa|
|Gene Name||neurotrophin 4|
|Background||NT4 is a member of a family of neurotrophic factors, neurotrophins, that control survival and differentiation of mammalian neurons. The expression of NT4 is ubiquitous and less influenced by environmental signals. While knock-outs of other neurotrophins including nerve growth factor, brain-derived neurotrophic factor, and neurotrophin 3 prove lethal during early postnatal development, NT4-deficient mice only show minor cellular deficits and develop normally to adulthood.|
|Protein Families||Secreted Protein, Druggable Genome|
|Protein Pathways||MAPK signaling pathway, Neurotrophin signaling pathway|
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