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NPC1 Rabbit Monoclonal Antibody

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SKU
TA427429
NPC1 Rabbit Monoclonal Antibody
Size:
100 ul
Conjugation:
Unconjugated
  $435.00
3 Weeks*
Bulk/Customize

View other "NPC1" antibodies

Specifications
Specifications
Product Data
Application ELISA, ICC, IHC, WB
Recommended Dilution WB:1/500-1000
IHC:1/50-200
ICC/IF:1/50-200
ELISA:Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Reactivity Human, Mouse, Rat
Antibody Host Rabbit
Isotype IgG
Clonality Monoclonal
Buffer PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3
Concentration lot specific
Purification Affinity purification
Conjugation Unconjugated
Storage Store at -20℃. Avoid freeze / thaw cycles.
Stability Stable for 12 months from date of receipt.
Shipping Blue Ice
Predicted Protein Size 142kDa
Database Link
Background This gene encodes a large protein that resides in the limiting membrane of endosomes and lysosomes and mediates intracellular cholesterol trafficking via binding of cholesterol to its N-terminal domain. It is predicted to have a cytoplasmic C-terminus, 13 transmembrane domains, and 3 large loops in the lumen of the endosome - the last loop being at the N-terminus. This protein transports low-density lipoproteins to late endosomal/lysosomal compartments where they are hydrolized and released as free cholesterol. Defects in this gene cause Niemann-Pick type C disease, a rare autosomal recessive neurodegenerative disorder characterized by over accumulation of cholesterol and glycosphingolipids in late endosomal/lysosomal compartments.
Reference Data
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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