Dxd Rabbit Monoclonal Antibody [Clone ID: 1A12]

SKU TA421202

Rabbit monoclonal anti-Dxd (ADC Payload) Antibody, Clone 1A12

Product Data

• Clone Name: 1A12
• Application: ELISA
• Recommended Dilution: ELISA 1:5000-10000
• Antibody Host: Rabbit
• Isotype: IgG
• Clonality: Monoclonal
• Reconstitution Method: Reconstitute with sterile, low-endotoxin water. See the COA for more details
• Concentration: Lot specific
• Purification: Purified from cell culture supernatant by affinity chromatography
• Conjugation: Unconjugated
• Storage: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing)
• Stability: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
• Shipping: Ambient
• Background: Dxd is a potent anti-cancer drug, acting as an alkaloid camptothecin analog and a DNA topoisomerase I inhibitor. It forms a stable complex with topoisomerase I and DNA, impeding DNA replication and inducing cancer cell death. Dxd is utilized as a payload in specific antibody-drug conjugates (ADCs), with examples such as trastuzumab deruxtecan targeting HER2 and patritumab deruxtecan targeting HER3.

Reference Data