CLEC7A Mouse Monoclonal Antibody [Clone ID: BD6]
Specifications
| Product Data | |
| Clone Name | BD6 |
|---|---|
| Application | FC |
| Antibody Host | Mouse |
| Isotype | IgG2b |
| Clonality | Monoclonal |
| Immunogen | NIH3T3 cells expressing full length Beta-glucan receptor. |
| Specificity | DECTIN-1 |
| Buffer | Phosphate buffered saline containing 0.09% Sodium Azide (NaN3) Label: ALEXA FLUOR® 488,ALEXA FLUOR® 647,FITC,Purified,RPE State: Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant Purified IgG - liquid |
| Concentration | lot specific |
| Conjugation | Unconjugated |
| Storage | +4°C, -20°C if preferred |
| Stability | Shelf life: one year from despatch. |
| Shipping | Ambient |
| Gene Name | C-type lectin domain family 7 member A |
| Database Link | |
| Background | Mouse anti Human Dectin-1 antibody, clone BD6 recognizes human Dectin-1, also known as beta-glucan receptor (βGR) or CD369. Dectin-1 is a C-type lectin domain family member. It is a major pathogen pattern-recognition receptor that binds beta-glucans, glucose polymers that form cell-wall components or exopolymers of yeasts, fungi and some bacteria. Beta-glucans have also been used experimentally and therapeutically as immunomodulators that enhance resistance to bacterial, yeast, viral and protozoan infections, as well as tumor formation. Dectin-1 also acts as a co-stimulatory molecule on T-cells to induce their proliferation and is necessary for the TLR2-mediated inflammatory response. It is highly expressed on peripheral blood leukocytes and dendritic cells.Human Dectin-1 has two major (βGR-A and βGR-B) and several minor isoforms. βGR-A and βGR-B differs by the presence and absence, respectively, of a stalk region. Mouse anti Human Dectin-1 antibody, clone BD6 recognizes βGR-A only. |
| Synonyms | BETA GLUCAN RECEPTOR,CD369 |
| Reference Data | |
| Protein Categories | CD Markers, Cytokines, Immune system diseases, Intracellular Proteins, Membrane Proteins |
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