Phospho Calnexin (Ser583) Rabbit Polyclonal Antibody
Specifications
| Product Data | |
| Application | IHC, IP, WB |
|---|---|
| Recommended Dilution | WB:1/10000-50000;IHC:1/50-1000;IP:1/50-200 |
| Reactivity | Human, Mouse, Rat |
| Antibody Host | Rabbit |
| Isotype | IgG |
| Clonality | Polyclonal |
| Immunogen | Synthetic phosphopeptide derived from human Calnexin around the phosphorylation site of Serine 583. |
| Specificity | p-Calnexin (S583) polyclonal antibody detects endogenous levels of Calnexin protein only when phosphorylated at Ser583 |
| Buffer | Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 |
| Concentration | 1mg/ml |
| Conjugation | Unconjugated |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. |
| Stability | 1 year |
| Shipping | Blue Ice |
| Predicted Protein Size | ~ 90 kDa |
| Gene Name | calnexin |
| Database Link | |
| Background | Calnexin and Calregulin (also called Calreticulin) are calcium-binding proteins that are localized to the endoplasmic reticulum—Calnexin to the membrane and Calregulin to the lumen. Calnexin is a type I membrane protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may play a role in assisting with protein assembly and in retaining unassembled protein subunits in the endoplasmic reticulum. Calregulin has both low- and high-affinity calcium-binding sites. Neither Calnexin nor Calregulin contains the calcium-binding “E-F hand” motif found in calmodulins. Calnexin and Calregulin are important for the maturation of glycoproteins in the endoplasmic reticulum and appear to bind many of the same proteins. |
| Synonyms | Calnexin; CANX; IP90; Major histocompatibility complex class I antigen-binding protein p88; p90 |
| Note | For research use only, not for use in diagnostic procedure. |
| Reference Data | |
| Protein Categories | Intracellular Proteins, Membrane Proteins |
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