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Phospho eEF2K (Ser366) Rabbit Polyclonal Antibody

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SKU
TA392889
eEF2K (phospho-S366) polyclonal antibody
Size:
100 ul
Conjugation:
Unconjugated
  $340.00
7 Weeks*
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Specifications
Specifications
Product Data
Application IHC, IP, WB
Recommended Dilution WB:1/500-1000;IHC:1/50-200;IP:1/10-100
Reactivity Human
Antibody Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen Synthetic phosphopeptide derived from human eEF2K around the phosphorylation site of Serine 366.
Specificity p-eEF2K (S366) polyclonal antibody detects endogenous levels of eEF2K protein when phosphorylated at Ser366.
Buffer Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Concentration 1mg/ml
Conjugation Unconjugated
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Stability 1 year
Shipping Blue Ice
Predicted Protein Size ~ 105 kDa
Gene Name eukaryotic elongation factor 2 kinase
Database Link
Background eEF2K is 105 kDa protein that is detected in skeletal muscle extracts and is phosphorylated rapidly by SAPK4, but poorly by p38, p38γ, JNK or ERK 2. SAPK4 phosphorylates eEF2K at Ser 359 and Ser 396 in vitro, causing its inactivation. The phosphorylation of eEF2K at Ser 359 is also induced by insulin-like growth factor-1. Ser 359 is in close proximity to Ser 366 and the Ser 366 residue also becomes phosphorylated in response to growth factors. eEF2K is phosphorylated by p70 S6 kinase at Ser 366 and this results in the inactivation of eEF2K, especially at low (micromolar) calcium concentrations.
Synonyms Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase; eEF-2 kinase; eEF-2K; EEF2K; Elongation factor 2 kinase
Note For research use only, not for use in diagnostic procedure.
Reference Data
Protein Categories Enzyme: Kinases, Intracellular Proteins
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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