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Phospho AhR (Ser36) Rabbit Polyclonal Antibody

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SKU
TA392655
AhR (phospho-S36) polyclonal antibody
Size:
100 ul
Conjugation:
Unconjugated
  $340.00
7 Weeks*
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Specifications
Specifications
Product Data
Application IHC, WB
Recommended Dilution WB:1/500-1000;IHC:1/50-200
Reactivity Human, Mouse, Rat
Antibody Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen Synthetic phosphopeptide derived from human AhR around the phosphorylation site of Serine 36.
Specificity p-AhR (S36) polyclonal antibody detects endogenous levels of AhR only when phosphorylated at Ser36.
Buffer Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Concentration 1mg/ml
Conjugation Unconjugated
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Stability 1 year
Shipping Blue Ice
Predicted Protein Size ~ 94 kDa
Gene Name aryl hydrocarbon receptor
Database Link
Background The Aryl Hydrocarbon Receptor (AHR), also known as the dioxin receptor, is a ligand-activated helix/loop/helix transcription factor found in a variety of vertebrate species. The known ligands for AHR are foreign planar aromatic compounds, such as polycyclic aromatic compounds and halogenated aromatic compounds such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).Unlike the steroid/thyroid hormone receptors, there is no known physiological ligand for the AH Receptor. Studies indicate that in non-ligand activated cells, AHR is found complexed with HSP90 predominantly in the cytoplasm. Upon binding to an agonist, the ligand-activated AHR is believed to transform to a nuclear, DNA binding form. This transformation process appears to involve dissociation of HSP90 from AHR followed by formation of a heterodimer with AHR nuclear translocator protein (Arnt). The AHR-ligand complex appears to initiate gene transcription of cytochrome P450 1A1.
Synonyms AHR; AhR; Ah receptor; Aryl hydrocarbon receptor; BHLHE76; bHLHe76; Class E basic helix-loop-helix protein 76
Note For research use only, not for use in diagnostic procedure.
Reference Data
Protein Categories Intracellular Proteins, Nervous system Diseases, Transciption Factors
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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