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FAS Rabbit Polyclonal Antibody

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SKU
TA388939
sFas Receptor Antibody
Size:
5 ug
Conjugation:
Unconjugated
  $810.00
5 Days*
Bulk/Customize

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Specifications
Specifications
Product Data
Application ELISA, WB
Recommended Dilution Sandwich ELISA: To detect Human sFas Receptor by sandwich ELISA (using 100ul/well antibody solution) a concentration of 0.5 - 2.0 μg/ml of this antibody is required. This antigen affinity purified antibody, in conjunction with ProSci’s Biotinylated Anti-Human sFas Receptor as a detection antibody, allows the detection of at least 0.2 - 0.4 ng/well of recombinant Human sFas Receptor.
Western Blot
To detect Human sFas Receptor by Western Blot analysis this antibody can be used at a concentration of 0.1 - 0.2 μg/ml. When used in conjunction with compatible secondary reagents the detection limit for recombinant Human sFas Receptor is 1.5 - 3.0 ng/lane, under either reducing or non-reducing conditions.
Reactivity Human
Antibody Host Rabbit
Clonality Polyclonal
Immunogen Produced from sera of rabbits immunized with highly pure recombinant Human sFas Receptor. Anti-Human sFas Receptor specific antibody was purified by affinity chromatography employing an immobilized Human sFas Receptor matrix.
Concentration lot specific
Purification sFas Receptor specific antibody was purified by affinity chromatography employing an immobilized Human sFas Receptor matrix
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Shipping Ambient
Database Link
Background Fas and Fas Ligand (FasL) belong to the TNF superfamily, and are type I and type II transmembrane proteins, respectively. Binding of FasL to Fas triggers apoptosis in Fas-bearing cells. The mechanism of apoptosis involves recruitment of pro-caspase 8 through an adaptor molecule called FADD, followed by processing of the pro-enzyme into active forms. These active caspases then cleave various cellular substrates, leading to the eventual cell death. sFasR is capable of inhibiting FasL-induced apoptosis by acting as a decoy receptor that serves as a sink for FasL. The full length Fas (receptor) is a 319 amino acid type I transmembrane protein, which contains a 157 amino acid extracellular domain, a 17 amino acid transmembrane domain, and a 145 amino acid cytoplasmic domain. Recombinant Human soluble Fas (sFas Receptor) is a 157 amino acid polypeptide (17.6 kDa) corresponding to the TNFR-homologous cysteine-rich extracellular Fas domain.
Reference Data
Protein Categories Cancer: Gastrointestinal, Cancer: Haematopoietic and Lymphoid, Cancer: Skin, CD Markers, Immune system diseases, Intracellular Proteins, Membrane Proteins, Secreated Proteins
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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