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Phospho STAT3 (Ser727) Rabbit Monoclonal Antibody [Clone ID: R05-7B2]

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SKU
TA385338
Phospho-STAT3 (Ser727) Rabbit monoclonal Antibody
Size:
100 ul
Conjugation:
Unconjugated
  $380.00
4 Weeks*
Bulk/Customize

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View other "Phospho STAT3 (Ser727)" antibodies

Specifications
Specifications
Product Data
Clone Name R05-7B2
Application ICC, WB
Recommended Dilution WB:1/1000-5000
ICC/IF:1/200-500
Reactivity Human, Rat
Antibody Host Rabbit
Isotype IgG
Clonality Monoclonal
Immunogen A synthetic phosphopeptide corresponding to residues surrounding Ser727 of human STAT3 (Phosphorylated)
Buffer 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Concentration lot specific
Purification Affinity Purified
Conjugation Unconjugated
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Stability 1 year
Shipping Blue Ice
Predicted Protein Size Calculated MW: 88 kDa; Observed MW: 88 kDa
Gene Name signal transducer and activator of transcription 3
Database Link
Background Swiss-Prot Acc.P40763.Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors (PubMed:10688651, PubMed:12359225, PubMed:12873986, PubMed:15194700, PubMed:17344214, PubMed:18242580, PubMed:23084476). Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene (PubMed:17344214). May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4 (PubMed:12873986). Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes (PubMed:12359225). Activated by IL31 through IL31RA (PubMed:15194700). Acts as a regulator of inflammatory response by regulating differentiation of naive CD4+ T-cells into T-helper Th17 or regulatory T-cells (Treg): deacetylation and oxidation of lysine residues by LOXL3, leads to disrupt STAT3 dimerization and inhibit its transcription activity (PubMed:28065600). Involved in cell cycle regulation by inducing the expression of key genes for the progression from G1 to S phase, such as CCND1 (PubMed:17344214). Mediates the effects of LEP on melanocortin production, body energy homeostasis and lactation . May play an apoptotic role by transctivating BIRC5 expression under LEP activation (PubMed:18242580). Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity (PubMed:23084476). Plays a crucial role in basal beta cell functions, such as regulation of insulin secretion .
Synonyms APRF; FLJ20882; HIES; MGC16063
Reference Data
Protein Categories Allergies and autoimmune diseases, Cancer: Head and Neck, Cytokines, Growth Factors, Intracellular Proteins, Transciption Factors
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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