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Phospho Rb (Ser780) Rabbit Polyclonal Antibody

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SKU
TA385136
Phospho-Rb (Ser780) Rabbit polyclonal Antibody
Size:
100 ul
Conjugation:
Unconjugated
  $380.00
4 Weeks*
Bulk/Customize

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Specifications
Specifications
Product Data
Application ELISA, ICC, IHC, WB
Recommended Dilution WB:1/500-2000
IHC:1/100-300
ICC/IF:1/200-1000
ELISA:1/10000
Reactivity Human, Mouse, Rat
Antibody Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen The antiserum was produced against synthesized peptide derived from human Retinoblastoma around the phosphorylation site of Ser780. AA range:751-800 (Phosphorylated)
Buffer Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Concentration lot specific
Purification Affinity Chromatography
Conjugation Unconjugated
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Stability 1 year
Shipping Blue Ice
Predicted Protein Size Observed MW (kDa):106
Gene Name RB transcriptional corepressor 1
Database Link
Background Swiss-Prot Acc.P06400.Key regulator of entry into cell division that acts as a tumor suppressor. Promotes G0-G1 transition when phosphorylated by CDK3/cyclin-C. Acts as a transcription repressor of E2F1 target genes. The underphosphorylated, active form of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Inhibits the intrinsic kinase activity of TAF1. Mediates transcriptional repression by SMARCA4/BRG1 by recruiting a histone deacetylase (HDAC) complex to the c-FOS promoter. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex .
Synonyms OSRC; osteosarcoma; p105-Rb; pp110; pRb; RB
Reference Data
Protein Categories ADC Targets, Cancer: Bladder, Cancer: Brain and CNS, Cancer: Gastrointestinal, Cancer: Haematopoietic and Lymphoid, Cancer: Lung, Cancer: Sarcoma, Growth Factors, Intracellular Proteins
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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