Ubiquitin (UBB) Rabbit Polyclonal Antibody
Specifications
| Product Data | |
| Application | ELISA, ICC/IF, IHC, WB |
|---|---|
| Recommended Dilution | WB,1:1000 - 1:5000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 ELISA,Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements. |
| Reactivity | Human, Mouse, Other (Wide Range), Rat |
| Antibody Host | Rabbit |
| Isotype | IgG |
| Clonality | Polyclonal |
| Buffer | Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |
| Concentration | lot specific |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage | Store at -20℃. Avoid freeze / thaw cycles. |
| Stability | Shelf life: one year from despatch. |
| Shipping | Blue Ice |
| Predicted Protein Size | 26kDa |
| Gene Name | ubiquitin B |
| Database Link | |
| Background | This gene encodes ubiquitin, one of the most conserved proteins known. Ubiquitin has a major role in targeting cellular proteins for degradation by the 26S proteosome. It is also involved in the maintenance of chromatin structure, the regulation of gene expression, and the stress response. Ubiquitin is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin moiety fused to an unrelated protein. This gene consists of three direct repeats of the ubiquitin coding sequence with no spacer sequence. Consequently, the protein is expressed as a polyubiquitin precursor with a final amino acid after the last repeat. An aberrant form of this protein has been detected in patients with Alzheimer's disease and Down syndrome. Pseudogenes of this gene are located on chromosomes 1, 2, 13, and 17. Alternative splicing results in multiple transcript variants. |
| Synonyms | FLJ25987; MGC8385; OTTHUMP00000064960; OTTHUMP00000064961; UBA80; UBCEP1; UBCEP2 |
| Reference Data | |
| Protein Categories | Intracellular Proteins |
Reviews
Documents
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| FAQs |
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Citations
Excessive autophagic degradation of MYLK3 causes sunitinib-induced cardiotoxicity
Pan, Zhu, Wang et al
Autophagy (2025)
Pan, Zhu, Wang et al
Autophagy (2025)
Cited by 6
AI Summary: In this study, OriGene’s anti-Ub antibody (TA382994) was used for immunoblotting to detect ubiquitinated proteins, contributing to the investigation of autophagic degradation mechanisms underlying sunitinib-induced cardiotoxicity.
Snippet: d incubated with PierceTM DYKDDDDK Magnetic Agarose (ThermoFisher, A36797). Last, the beads were rinsed with elution buffer and neutralization buffer solution and then subjected to direct immunoblotting with anti-Ub (ORIGENE, TA382994) or anti-FLAG (Sigma-Aldrich, F1804) antibody. Overexpression of SQSTM1-ΔUBA p
Showing 1-1 of 1 papers.
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