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Collagen IV (COL4A3) Rabbit Polyclonal Antibody

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SKU
TA374968
COL4A3 Rabbit polyclonal Antibody
Size:
100 ul
Conjugation:
Unconjugated
  $410.00
3 Weeks*
Bulk/Customize

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Specifications
Specifications
Product Data
Application ELISA, ICC/IF, WB
Recommended Dilution WB,1:500 - 1:1000
IF/ICC,1:50 - 1:200
ELISA,Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Reactivity Human, Mouse, Rat
Modification Unmodified
Antibody Host Rabbit
Isotype IgG
Clonality Polyclonal
Buffer Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Concentration lot specific
Purification Affinity purification
Conjugation Unconjugated
Storage Store at -20℃. Avoid freeze / thaw cycles.
Stability Shelf life: one year from despatch.
Shipping Blue Ice
Predicted Protein Size 162kDa
Gene Name collagen type IV alpha 3 chain
Database Link
Background Type IV collagen, the major structural component of basement membranes, is a multimeric protein composed of 3 alpha subunits. These subunits are encoded by 6 different genes, alpha 1 through alpha 6, each of which can form a triple helix structure with 2 other subunits to form type IV collagen. This gene encodes alpha 3. In the Goodpasture syndrome, autoantibodies bind to the collagen molecules in the basement membranes of alveoli and glomeruli. The epitopes that elicit these autoantibodies are localized largely to the non-collagenous C-terminal domain of the protein. A specific kinase phosphorylates amino acids in this same C-terminal region and the expression of this kinase is upregulated during pathogenesis. This gene is also linked to an autosomal recessive form of Alport syndrome. The mutations contributing to this syndrome are also located within the exons that encode this C-terminal region. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter.
Synonyms tumstatin
Reference Data
Protein Categories Intracellular Proteins, Secreated Proteins
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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