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XPB (ERCC3) Rabbit Polyclonal Antibody

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SKU
TA369739
ERCC3 rabbit polyclonal antibody
  • TA369739 is a possible alternative to TA323737.
Size:
100 ul
Conjugation:
Unconjugated
  $310.00
4 Weeks*
Bulk/Customize

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Specifications
Specifications
Product Data
Application IHC, WB
Recommended Dilution WB: 1000-5000
WB positive control: Hela cell lysate
IHC: 50-200
Positive control: Human colorectal cancer
Predicted cell location: Nucleus
Reactivity Human, Mouse, Rat
Antibody Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen Fusion protein of human ERCC3
Buffer pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Concentration lot specific
Purification Antigen affinity purification
Conjugation Unconjugated
Storage Store at -20°C.
Stability 1 year
Shipping Blue Ice
Predicted Protein Size 89 kDa
Gene Name ERCC excision repair 3, TFIIH core complex helicase subunit
Database Link
Background ATP-dependent 3'-5' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATPase activity of XPB/ERCC3, but not its helicase activity, is required for DNA opening. In transcription, TFIIH has an essential role in transcription initiation (PubMed:8157004, PubMed:30894545). When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape (PubMed:8157004). The ATP-dependent helicase activity of XPB/ERCC3 is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.
Synonyms BTF2; BTF2-p89; GTF2H; RAD25; TFIIH; XPB; XPBC
Reference Data
Protein Categories Intracellular Proteins, Nervous system: Neurodegenerative diseases
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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