GTSE1 Rabbit Polyclonal Antibody
Specifications
| Product Data | |
| Application | IHC |
|---|---|
| Recommended Dilution | IHC: 20-100 Positive control: Human cervical cancer Predicted cell location: Cytoplasm |
| Reactivity | Human, Mouse |
| Antibody Host | Rabbit |
| Isotype | IgG |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide of human GTSE1 |
| Buffer | pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Concentration | lot specific |
| Purification | Antigen affinity purification |
| Conjugation | Unconjugated |
| Storage | Store at -20°C. |
| Stability | 1 year |
| Shipping | Blue Ice |
| Gene Name | G2 and S-phase expressed 1 |
| Database Link | |
| Background | The protein encoded by this gene is only expressed in the S and G2 phases of the cell cycle, where it colocalizes with cytoplasmic tubulin and microtubules. In response to DNA damage, the encoded protein accumulates in the nucleus and binds the tumor suppressor protein p53, shuttling it out of the nucleus and repressing its ability to induce apoptosis. |
| Synonyms | B99; GTSE-1; OTTHUMP00000197503 |
| Reference Data | |
| Protein Categories | Intracellular Proteins |
Reviews
Documents
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| FAQs |
| SDS |
Citations
A liquid-like spindle domain promotes acentrosomal spindle assembly in mammalian oocytes
So, Seres, Steyer et al
Science (2019) 364 (6447) DOI: 10.1126/science.aat9557
So, Seres, Steyer et al
Science (2019) 364 (6447) DOI: 10.1126/science.aat9557
AI Summary: OriGene’s recombinant GTSE1 protein was used to preincubate and validate the specificity of anti-GTSE1 antibodies in immunofluorescence experiments, ensuring accurate detection of GTSE1 in the study of acentrosomal spindle assembly in mammalian oocytes.
Snippet: Oocytes were fixed, extracted, and blocked as for routine immunofluorescence. Rabbit polyclonal anti-CHC17, polyclonal anti-GTSE1, and monoclonal anti-TACC3 were preincubated with peptide PQAPFGYGYTAPPYGQPQPGFGYSM (GenScript), recombinant GTSE1 (OriGene), and recombinant GST-TACC3-His6 (homemade), respectively, before applied to oocytes as previously described (90)
Showing 1-1 of 1 papers.
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