RNF20 Rabbit Polyclonal Antibody
Specifications
| Product Data | |
| Application | IHC, WB |
|---|---|
| Recommended Dilution | WB: 500-2000 WB positive control: Hela, Jurkat, 231, A375, A172 and Lovo cells IHC: 10-50 Positive control: Human esophagus cancer Predicted cell location: Nucleus |
| Reactivity | Human, Mouse |
| Antibody Host | Rabbit |
| Isotype | IgG |
| Clonality | Polyclonal |
| Immunogen | Fusion protein of human RNF20 |
| Buffer | pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Concentration | lot specific |
| Purification | Antigen affinity purification |
| Conjugation | Unconjugated |
| Storage | Store at -20°C. |
| Stability | 1 year |
| Shipping | Blue Ice |
| Predicted Protein Size | 114 kDa |
| Gene Name | ring finger protein 20 |
| Database Link | |
| Background | The protein encoded by this gene shares similarity with BRE1 of S. cerevisiae. The protein encoded by this human gene is an E3 ubiquitin ligase that regulates chromosome structure by monoubiquitinating histone H2B. This protein acts as a putative tumor suppressor and positively regulates the p53 tumor suppressor as well as numerous histone H2A and H2B genes. In contrast, this protein also suppresses the expression of several protooncogenes and growth-related genes, including many genes that are induced by epidermal growth factor. |
| Synonyms | BRE1; BRE1-A; BRE1A; FLJ11189; FLJ20382; hBRE1; KAIA2779; KIAA2779; MGC129667; MGC129668 |
| Reference Data | |
| Protein Categories | Growth Factors, Intracellular Proteins |
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