Itgam Rat Monoclonal Antibody [Clone ID: M1/70]
$980.00
2 Weeks*
Specifications
| Product Data | |
| Clone Name | M1/70 |
|---|---|
| Application | ELISA, IHC |
| Recommended Dilution | Each lot of this antibody has been tested and validated for immunohistochemistry (IHC), frozen and paraffin sections. Has also been described to work in FACS, western blotting and immune precipitation. Approximate working dilution for IHC: Frozen sections: 5µg/ml (1:100) Paraffin sections: does not react on routinely processed paraffin sections. Optimal dilutions should be determined by the end user. Suggested positive control: Mouse spleen. |
| Reactivity | Mouse |
| Antibody Host | Rat |
| Isotype | IgG2b |
| Clonality | Monoclonal |
| Immunogen | T-cell enriched splenocytes from B10 mice. |
| Specificity | Mouse: monocytes, macrophages, granulocytes, endothelial
and NK cells.
Other species: human. Epitope: The antigen is an epitope of the CD11b integrin on the αm chain. Distribution: Isolated cells: Granulocytes, monocytes: antigen expression increases with cell maturation. |
| Buffer | Affinity purified from ascitic fluid, lyophilized. Reconstitute by adding 0.5ml distilled water. This stock solution contains 0.5mg/ml IgG, phosphate buffered saline pH 7.2 (PBS), 5mg/ml bovine serum albumin (BSA) as a stabilizer and 0.05% (v/v) Kathon CG as a preservative. |
| Concentration | lot specific |
| Conjugation | Unconjugated |
| Storage | Original vial: 6 months at 4° - 8°C. |
| Shipping | Blue Ice |
| Gene Name | integrin alpha M |
| Database Link | |
| Background | Monoclonal antibody M1/70 is useful for detecting CD11b on myeloid cells and for myeloid- endothelial cell interaction studies. The antibody detects the 170kDa α subunit of Mac-1 which mediates adhesion to ICAM-1 (CD54) and C3bi. Mac-1 is expressed on granulocytes, macrophages, natural killer cells, and B-1 cells in the peritoneal and pleural cavities. Mac-1 is up-regulated on neutrophils after activation. This particular clone blocks cell adherence and C3bi binding but does not block cell mediated lysis. It has been used for the characterisation of LFA-1 immunodeficiency. |
| Synonyms | CD11B; CR3A; MAC-1; MAC1A; MGC117044; MO1A; SLEB6 |
| Reference Data | |
| Protein Categories | CD Markers, Intracellular Proteins, Membrane Proteins |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Citations
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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