JAGN1 Rabbit Polyclonal Antibody

SKU TA355006

Rabbit Polyclonal Anti-JAGN1 Antibody

Product Data

• Application: IHC, WB
• Recommended Dilution: WB: 1-2µg/ml. IHC starting at 2.5µg/mL.
• Reactivity: Human, Mouse, Rat
• Antibody Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: JAGN1 antibody was raised against a 19 amino acid peptide near the carboxy terminus of human JAGN1. The immunogen is located within the last 50 amino acids of JAGN1.
• Buffer: JAGN1 antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: JAGN1 antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Shipping: Blue Ice
• Predicted Protein Size: Predicted: 20 kDa; Observed: 25 kDa
• Gene Name: jagunal homolog 1
• Database Link:
  NP_115881
  Q8N5M9
• Background: JAGN1 is the human ortholog of a gene originally identified in Drosophila melanogaster. It is a transmembrane protein that functions in the early secretory pathway and is necessary for neutrophil differentiation and survival. Individuals with mutations in the JAGN1 gene causes aberrant myeloid cell homeostasis and severe congenital neutropenia (SCN) (1). JAGN1-mutant granulocytes are characterized by ultrastructural defects, aberrant N-glycosylation of multiple proteins, and increased apoptosis (1). Mice lacking this gene could not mount and efficient neutrophil-dependent immune response to a human fungal pathogen (2).
• Synonyms: FLJ14602; GL009
• Note: JAGN1 antibody can be used for detection of JAGN1 by Western blot at 1 - 2 µg/ml. Antibody can also be used for immunohistochemistry starting at 2.5 µg/mL.

Reference Data