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Neurofibromin (NF1) Rabbit Polyclonal Antibody

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SKU
TA354839
Rabbit anti Neurofibromin(paired S2741) Polyclonal Antibody
Size:
100 ug
Conjugation:
Unconjugated
  $450.00
5 Days*
Bulk/Customize

Frequently Bought Together (2)

TA811000S beta Actin Mouse Monoclonal Antibody, Clone OTI1, Loading Control 30 ul
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LY426897 Transient overexpression lysate of neurofibromin 1 (NF1), transcript variant 3 (as WB positive control) 100 ug
$436.00

View other "Neurofibromin or NM_000267" antibodies

Specifications
Specifications
Product Data
Application Dot, WB
Recommended Dilution WB 0.1-1 µg/ml ELISA 0.01-0.1 µg/ml IP 2-5 µg/ml IHC 2-10 µg/ml FC 5-10 µg/ml
Reactivity Human
Antibody Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen A synthetic peptide surrounding the epitope –PTSPY- without phosphorylation at human neurofibromin. This sequence is identical among human, rat, mouse, chicken, bovine and dog.
Buffer This affinity purified antibody is supplied in sterile Tris-buffered saline (pH7.2) containing antibody stabilizer.
Purification The Rabbit IgG is purified by Epitope Affinity Purification
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Shipping Blue Ice
Predicted Protein Size 240 kDa
Gene Name neurofibromin 1
Database Link
Background The neurofibromatosis type 1 (NF1) tumor suppressor (neurofibromin) is thought to play crucial roles in cellular Ras- and cAMP-dependent kinase (PKA)-associated signals. The absence of or alteration of the neurofibromin protein may lead to neurofibromatosis disease. Recently, a cellular neurofibromin-associating protein, NG,NG-dimethylarginine dimethylaminohydrolase (DDAH)has been identified as a cellular NO/NOS regulator which increases PKA phosphorylation of native neurofibromin in a dose-dependent manner. The PKA accessibility of neurofibromin regulated via DDAH interaction may modulate the cellular function of neurofibromin that is implicated in NF1-related pathogenesis.
Synonyms NFNS; VRNF; WSS
Reference Data
Protein Categories Cancer: Endocrine, Cancer: Haematopoietic and Lymphoid, Growth Factors, Intracellular Proteins, Membrane Proteins
Protein Families Druggable Genome
Protein Pathways MAPK signaling pathway
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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