Tenascin C (TNC) Rabbit Polyclonal Antibody
Specifications
| Product Data | |
| Application | IHC, WB |
|---|---|
| Recommended Dilution | WB 0.1-1 µg/ml ELISA 0.01-0.1 µg/ml IP 2-5 µg/ml IHC 2-10 µg/ml FC 5-10 µg/ml |
| Reactivity | Human, Mouse, Rat |
| Antibody Host | Rabbit |
| Isotype | IgG |
| Clonality | Polyclonal |
| Immunogen | A synthetic peptide corresponding to the internal segment of Tenascin C protein. This sequence is identical among human, rat and mouse. |
| Buffer | This affinity purified antibody is supplied in sterile Phosphate buffered saline (pH7.2) containing antibody stabilizer. |
| Purification | The Rabbit IgG is purified by Epitope Affinity Purification |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Predicted Protein Size | ~240 kDa |
| Gene Name | tenascin C |
| Database Link | |
| Background | Tenascin-C (TN-C) is an extracellular matrix glycoprotein expressed during embryonic development, as well as in wound healing and cancer invasion in various tissues. It is usually derived from myofibroblasts in the cancer microenvironment. It has diverse functions, including weakening of cell adhesion, up-regulating the expression and activity of matrix metalloproteinases, modulating inflammatory responses, promoting recruitment of myofibroblasts, and enhancing fibrosis. TN-C could exert both harmful and protective effects and might be a therapeutic target as a key molecule in the control of the balance of beneficial and undesirable cellular responses during tissue remodeling. Cancer cell-specific TNC is a novel indicator of poor prognosis. |
| Synonyms | 150-225; DFNA56; GMEM; GP; HXB; JI; TN; TN-C |
| Reference Data | |
| Protein Categories | ADC Targets, Intracellular Proteins, Nervous system Diseases, Secreated Proteins |
| Protein Families | Druggable Genome, ES Cell Differentiation/IPS, Secreted Protein, Transmembrane |
| Protein Pathways | ECM-receptor interaction, Focal adhesion |
Reviews
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Citations
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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