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Ptk2 Rabbit Polyclonal Antibody

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SKU
TA354484
Rabbit anti FAK(pY576) Polyclonal Antibody
Size:
100 ug
Conjugation:
Unconjugated
  $430.00
5 Days*
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Specifications
Specifications
Product Data
Application WB
Recommended Dilution WB 0.1-1 µg/ml ELISA 0.01-0.1 µg/ml IP 2-5 µg/ml IHC 2-10 µg/ml FC 5-10 µg/ml
Reactivity Human
Antibody Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen A synthetic peptide surrounding to the epitope -STYYKA- with a phosphorylation site at Tyrosine 576 of human FAK protein. This sequence is identical among human, mouse and rat.
Buffer This affinity purified antibody is supplied in sterile Tris-buffered saline (pH7.2) containing antibody stabilizer.
Purification The Rabbit IgG is purified by site-modified Epitope Affinity Purification.
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Shipping Blue Ice
Predicted Protein Size 125 kDa
Gene Name protein tyrosine kinase 2
Database Link
Background Focal adhesion kinase (FAK) gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinase but lacks significant sequence similarity to kinase from other subfamilies. Activation by phosphorylation of Y397, Y576/577 and Y863 of FAK protein may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. Increased FAK expression has been correlated with the enhanced motility and invasiveness of human tumor cells, as well as with promoting increased cell proliferation
Synonyms FADK; FAK; FAK1; FRNK; pp125FAK
Reference Data
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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