Jagged 2 (JAG2) Rabbit Polyclonal Antibody
Specifications
| Product Data | |
| Application | IHC |
|---|---|
| Recommended Dilution | IHC: 50-200 Positive control: Human colon cancer Predicted cell location: Cytoplasm or Nucleus |
| Reactivity | Human |
| Antibody Host | Rabbit |
| Isotype | IgG |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide of human JAG2 |
| Buffer | pH7.4 PBS, 0.05% NaN3, 40% Glyceroln |
| Concentration | lot specific |
| Purification | Antigen affinity purification |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Gene Name | jagged 2 |
| Database Link | |
| Background | The Notch signaling pathway is an intercellular signaling mechanism that is essential for proper embryonic development. Members of the Notch gene family encode transmembrane receptors that are critical for various cell fate decisions. The protein encoded by this gene is one of several ligands that activate Notch and related receptors. Two transcript variants encoding different isoforms have been found for this gene. |
| Synonyms | HJ2; SER2 |
| Reference Data | |
| Protein Categories | Growth Factors, Membrane Proteins |
| Protein Families | Druggable Genome, Transmembrane |
| Protein Pathways | Notch signaling pathway |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Citations
CD146 regulates the stemness and chemoresistance of hepatocellular carcinoma via JAG2-NOTCH signaling
Yan, Lu, Gao et al
Cell Death Dis (2025) 16 (1), 150 DOI: 10.1038/s41419-025-07470-x
Yan, Lu, Gao et al
Cell Death Dis (2025) 16 (1), 150 DOI: 10.1038/s41419-025-07470-x
Cited by 10
AI Summary: In this study, the OriGene rabbit anti-JAG2 antibody (Cat# TA351308) was used for immunohistochemistry to detect JAG2 expression, helping to elucidate the role of JAG2 in CD146-mediated stemness and chemoresistance in hepatocellular carcinoma.
Snippet: Antibodies for IHC included rabbit anti-CD133 (Abcam, Cat#A0219, 1:100), rabbit anti-Oct-4 (Abcam, Cat#A7920, 1:100), rabbit anti-JAG2 (Origene, Cat#TA351308,1:200) and rabbit anti-Ki67 (Proteintech, Cat#27309-1-AP,1:100), and rabbit anti-CD146 (Abcam, Cat#ab75769, 1:500)
Showing 1-1 of 1 papers.
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