MUM1 (IRF4) Rabbit Polyclonal Antibody
Specifications
| Product Data | |
| Application | WB |
|---|---|
| Recommended Dilution | WB: 200-1000 WB positive control: Mouse lung tissue |
| Reactivity | Human, Mouse |
| Antibody Host | Rabbit |
| Isotype | IgG |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide of human IRF4 |
| Buffer | pH7.4 PBS, 0.05% NaN3, 40% Glyceroln |
| Concentration | lot specific |
| Purification | Antigen affinity purification |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Predicted Protein Size | 52 kDa |
| Gene Name | interferon regulatory factor 4 |
| Database Link | |
| Background | The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6;14)(p25;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found for this gene. |
| Synonyms | LSIRF; MUM1; NF-EM5; SHEP8 |
| Reference Data | |
| Protein Categories | Intracellular Proteins, Transciption Factors |
| Protein Families | Druggable Genome, Transcription Factors |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Citations
Transcriptional Landscape of CUT-Class Homeobox Genes in Blastic Plasmacytoid Dendritic Cell Neoplasm
Nagel, Rand, Pommerenke et al
IJMS (2024) 25 (5), 2764 DOI: 10.3390/ijms25052764
Nagel, Rand, Pommerenke et al
IJMS (2024) 25 (5), 2764 DOI: 10.3390/ijms25052764
Cited by 1
AI Summary: OriGene contributed to this paper by providing the IRF4 antibody (#TA351302), which was used for protein analysis via Western blot to study the regulation and expression of homeobox genes in dendritic cells and BPDCN.
Snippet: Proteins were transferred onto nitrocellulose membranes (Bio-Rad, München, Germany) and blocked with 5% dry milk powder dissolved in phosphate-buffered saline (PBS). The following antibodies were used: alpha-Tubulin (Sigma, #T6199), CUX2 (Abnova, #H00023316-M03), IRF4 (Origene, #TA351302) and EPAS (MyBioSource, #MBS9127904). …
Showing 1-1 of 1 papers.
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