SDHA Rabbit Polyclonal Antibody
Specifications
| Product Data | |
| Application | IHC, WB |
|---|---|
| Recommended Dilution | WB: 500-2000 WB positive control: Mouse brain tissue and Hela cells, Jurkat cells and Mouse heart tissue IHC: 30-150 Positive control: Human breast cancer Predicted cell location: Cytoplasm |
| Reactivity | Human, Mouse, Rat |
| Antibody Host | Rabbit |
| Isotype | IgG |
| Clonality | Polyclonal |
| Immunogen | Fusion protein of human SDHA |
| Buffer | pH7.4 PBS, 0.05% NaN3, 40% Glyceroln |
| Concentration | lot specific |
| Purification | Antigen affinity purification |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Predicted Protein Size | 73 kDa |
| Gene Name | succinate dehydrogenase complex flavoprotein subunit A |
| Database Link | |
| Background | This gene encodes a major catalytic subunit of succinate-ubiquinone oxidoreductase, a complex of the mitochondrial respiratory chain. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. Mutations in this gene have been associated with a form of mitochondrial respiratory chain deficiency known as Leigh Syndrome. A pseudogene has been identified on chromosome 3q29. |
| Synonyms | CMD1GG; FP; PGL5; SDH1; SDH2; SDHF |
| Reference Data | |
| Protein Categories | Cancer: Endocrine, Cardiovascular diseases, Intracellular Proteins |
| Protein Families | Druggable Genome |
| Protein Pathways | Alzheimer's disease, Citrate cycle (TCA cycle), Huntington's disease, Metabolic pathways, Oxidative phosphorylation, Parkinson's disease |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Citations
Activity increase in respiratory chain complexes by rubella virus with marginal induction of oxidative stress
Claus, Schönefeld, Hübner et al
J Virol (2013) 87 (15), 8481-92 DOI: 10.1128/JVI.00533-13
Claus, Schönefeld, Hübner et al
J Virol (2013) 87 (15), 8481-92 DOI: 10.1128/JVI.00533-13
AI Summary: OriGene products contributed to this study by providing specific reagents, including anti-Mfn2 antibody (TA801192) and NRF1 cDNA clone (RC202598), which were used to assess mitochondrial biogenesis and structure markers in the context of rubella virus-induced changes in mitochondrial respiratory chain activity.
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