OATP2 (SLCO1B1) Rabbit Polyclonal Antibody

SKU TA349179

Rabbit Polyclonal Anti-SLCO1B1 Antibody

Product Data

• Application: ELISA, ICC, IF, WB
• Recommended Dilution: SLCO1B1 antibody can be used for detection of SLCO1B1 by Western blot at 1 - 2 µg/ml. For immunofluorescence start at 20 µg/mL. ; Antibody validated: Western Blot in human samples; Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
• Reactivity: Human
• Antibody Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: SLCO1B1 antibody was raised against a 14 amino acid peptide near the carboxy terminus of human SLCO1B1.
• Specificity: SLCO1B1 antibody is human specific. At least four isoforms of SLCO1B1 are known to exist. This antibody is predicted to not cross-react with other SLCO1B proteins.
• Buffer: PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: SLCO1B1 antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at +4°C as received.
• Stability: Stable for 12 months from date of receipt.
• Shipping: Blue Ice
• Predicted Protein Size: Predicted: 76 kDa; Observed: 75 kDa
• Gene Name: solute carrier organic anion transporter family member 1B1
• Database Link:
  NP_006437
  Q9Y6L6
• Background: SLCO1B1 is a transmembrane receptor that mediates the sodium-independent uptake of numerous endogenous compounds including bilirubin, 17-beta-glucuronosyl estradiol and may play an important role in the clearance of bile acids and organic anions from the liver (1,2). It contains one Kazal-like domain and belongs to the organo-anion transporter family (2,3). SLCO1B1 is highly expressed in liver and is localized to the basolateral hepatocyte membrane. It is responsible for the hepatic uptake of the liver-specific hydroxymethylglutaryl-CoA reductase inhibitor in mouse, rat and human (3,4).
• Synonyms: FAT10; GABBR1; UBD-3

Reference Data