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RNF70 (PJA1) Rabbit Polyclonal Antibody

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SKU
TA349130
Rabbit Polyclonal Anti-PJA1 Antibody
Size:
100 ug
Conjugation:
Unconjugated
  $640.00
5 Days*
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Specifications
Specifications
Product Data
Application IF, IHC, WB
Recommended Dilution WB: 1 - 2 ug/mL, IHC: 5 ug/mL, IF: 20 ug/mL
Reactivity Human, Mouse, Rat
Antibody Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen PJA1 antibody was raised against a 19 amino acid peptide near the amino terminus of human PJA1.
Buffer PBS containing 0.02% sodium azide.
Concentration 1 mg/ml
Purification PJA1 antibody is affinity chromatography purified via peptide column.
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Shipping Blue Ice
Predicted Protein Size Predicted: 71 kDa; Observed: 71 kDa
Gene Name praja ring finger ubiquitin ligase 1
Database Link
Background Ubiquitinization is an important cellular degradation process requiring sequential reactions that are mediated by three enzymes: E1, E2 and E3. PJA1, also known as Praja1 and RING finger protein 70, is a 643 amino acid E2-dependent E3-ubiquitin ligase that is abundantly expressed in the brain (1,2). Through interaction and activation with the E2-ubiquitin ligase UBC4, PJA1 mediates substrate-specific ubiquitination via its RING finger domain and facilitates ubiquitination (3). Overexpression of PJA1 in gastrointestinal cancers suggests that it may be responsible for the degradation of some anti-oncogenic proteins (4,5).
Synonyms BIgR; IGSF4B; Necl-1; NECL1; synCAM3; TSLL1
Reference Data
Protein Categories Intracellular Proteins
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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