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Fibroblast activation protein, alpha (FAP) Rabbit Polyclonal Antibody

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SKU
TA347770
Rabbit Polyclonal Anti-FAP-1 Antibody
Size:
100 ug
Conjugation:
Unconjugated
  $380.00
4 Weeks*
Bulk/Customize

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View other "Fibroblast activation protein, alpha or NM_004460" antibodies

Specifications
Specifications
Product Data
Application WB
Recommended Dilution WB: 1:500-1:2000
Reactivity Human, Mouse, Rat
Antibody Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen The immunogen for anti-FAP-1 Antibody: A synthesized peptide derived from human FAP-1
Buffer Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20?. Stable for 12 months from date of receipt
Concentration lot specific
Purification Immunogen affinity purified
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Shipping Blue Ice
Predicted Protein Size 88 kDa
Gene Name fibroblast activation protein alpha
Database Link
Background PTPN13 Tyrosine phosphatase which regulates negatively FAS- induced apoptosis and NGFR-mediated pro-apoptotic signaling. Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily. Interacts with TRIP6 and TNFRSF6 (Fas receptor) through its second PDZ domain. Interacts with the C-terminal SVP motif of NGFR through its third PDZ domain.
Synonyms DPPIV; FAPA; SIMP
Note FAP-1 Antibody detects endogenous levels of FAP-1
Reference Data
Protein Categories CAR-T Targets, Enzyme: Peptidases, Intracellular Proteins, Secreated Proteins
Protein Families Druggable Genome, Protease, Transmembrane
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Documents
Resources

file-alt Citations

HIF-1α is necessary for activation and tumour-promotion effect of cancer-associated fibroblasts in lung cancer
Zhang, Bian, Wang et al
J Cell Mol Med (2021)
Cited by 46
AI Summary: In this study, OriGene's anti-FAP antibody (TA347770) was used to detect fibroblast activation protein, helping to assess the activation status of cancer-associated fibroblasts in lung cancer tissues.
Snippet: The primary antibodies were used as follows: anti- α- SMA (Abcam, #ab21027;diluted 1:1000), anti- COL1A2 (Proteintech, #14695- 1- AP;diluted 1:1000), anti- HIF- 1α (Abcam, #ab179483;diluted 1:1000), anti- FAP (Origene, #TA347770;diluted 1:1000), anti- CCR5
WB
Inhibition of Connexin 43 translocation on mitochondria accelerates CoCl2-induced apoptotic response in a chemical model of hypoxia
Pecoraro, Pinto, Popolo
Toxicol In Vitro (2018) 47, 120-128 DOI: 10.1016/j.tiv.2017.11.004
Cited by 31
AI Summary: In this study, OriGene products—including the Cx43 (Connexin 43) antibody (Cat# TA500648) and Hsp90 antibody (Cat# TA500494)—were used for immunoblotting and immunofluorescence analyses to assess protein expression and localization, thereby contributing to the investigation of mitochondrial Cx43’s role in cardiomyocyte apoptosis under hypoxic conditions.
Showing 1-2 of 2 papers.
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