hHR23A (RAD23A) Rabbit Polyclonal Antibody
Specifications
| Product Data | |
| Application | IHC, WB |
|---|---|
| Recommended Dilution | WB, IHC |
| Reactivity | Human |
| Antibody Host | Rabbit |
| Isotype | IgG |
| Clonality | Polyclonal |
| Immunogen | The immunogen for anti-RAD23A antibody: synthetic peptide directed towards the N terminal of human RAD23A. Synthetic peptide located within the following region: VPSSGSSGREEDAASTLVTGSEYETMLTEIMSMGYERERVVAALRASYNN |
| Buffer | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Purification | Protein A Purified |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Predicted Protein Size | 40 kDa |
| Gene Name | RAD23 homolog A, nucleotide excision repair protein |
| Database Link | |
| Background | RAD23A is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in nucleotide excision repair (NER). This protein was shown to interact with, and elevate the nucleotide excision activity of 3-methyladenine-DNA glycosylase (MPG), which suggested a role in DNA damage recognition in base excision repair. This protein contains an N-terminal ubiquitin-like domain, which was reported to interact with 26S proteasome, as well as with ubiquitin protein ligase E6AP, and thus suggests that this protein may be involved in the ubiquitin mediated proteolytic pathway in cells.The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in nucleotide excision repair (NER). This protein was shown to interact with, and elevate the nucleotide excision activity of 3-methyladenine-DNA glycosylase (MPG), which suggested a role in DNA damage recognition in base excision repair. This protein contains an N-terminal ubiquitin-like domain, which was reported to interact with 26S proteasome, as well as with ubiquitin protein ligase E6AP, and thus suggests that this protein may be involved in the ubiquitin mediated proteolytic pathway in cells. |
| Synonyms | HHR23A; HR23A |
| Note | Immunogen Sequence Homology: Dog: 100%; Pig: 100%; Rat: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Guinea pig: 100%; Bovine: 93% |
| Reference Data | |
| Protein Categories | Intracellular Proteins |
| Protein Families | Druggable Genome |
| Protein Pathways | Nucleotide excision repair |
Reviews
Documents
| Product Manuals |
| FAQs |
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Citations
Ubiquitin-binding site 2 of ataxin-3 prevents its proteasomal degradation by interacting with Rad23
Blount, Tsou, Ristic et al
Nat Commun (2014) 5, 4638 DOI: 10.1038/ncomms5638
Blount, Tsou, Ristic et al
Nat Commun (2014) 5, 4638 DOI: 10.1038/ncomms5638
Cited by 76
AI Summary: OriGene’s anti-Rad23A antibody (rabbit polyclonal YH62308) was used in this study to detect and analyze Rad23A protein levels, supporting investigations into the interaction between ataxin-3 and Rad23A in proteasomal degradation pathways.
Snippet: Anti-ataxin-3 (MJD;rabbit polyclonal, 1:15,000 (ref. 53)), anti ataxin-3 monoclonal (clone 1H9, mouse, 1:500-1:1,000;Millipore), anti-HA (rabbit polyclonal Y11, 1:500;Santa Cruz Biotech), anti-tubulin (mouse monoclonal T5168, 1:10,000;Sigma-Aldrich), anti-GAPDH (mouse monoclonal MAB374, 1:500;Millipore), anti-Rad23A (rabbit polyclonal YH62308, 1:5,000;Origene),
Showing 1-1 of 1 papers.
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