Synaptophysin (SYP) Rabbit Polyclonal Antibody
Specifications
| Product Data | |
| Application | ICC/IF, IHC, WB |
|---|---|
| Recommended Dilution | Immunohistochemistry-Frozen, Immunohistochemistry: 1:100, Immunocytochemistry/ Immunofluorescence: 1:250, Western Blot: 1.0 ug/ml, Immunohistochemistry-Paraffin: 1:100 |
| Reactivity | Human, Mouse, Primate |
| Antibody Host | Rabbit |
| Clonality | Polyclonal |
| Immunogen | A synthetic peptide made to an C-terminal portion of the human Synaptophysin protein (between residues 230-313) UniProt P08247 |
| Buffer | PBS, 0.02% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Concentration | lot specific |
| Purification | Immunogen affinity purified |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Gene Name | synaptophysin |
| Database Link | |
| Background | Communication in the nervous system is dependent on the exocytosis of neurotransmitter-containing synaptic vesicles that release their contents at the synapses following membrane depolarization. Synaptophysin (SYP) is a major 38 kDa tetraspan membrane protein of small synaptic vesicles that plays an essential role in targeting synaptic vesicles to the presynaptic membrane. Synaptophysin directly interacts with the essential membrane fusion v-SNARE protein, synaptobrevin/VAMP2, and targets it to the presynaptic membrane (PMID: 14528015). Thus, synaptophysin is required for proper targeting of VAMP2 and synaptic vesicles. Synaptophysin is localized to the trans-Golgi cisternae and then accumulates to the presynaptic membrane in a microtubule dependent manner (PMID: 8227215). |
| Synonyms | MRX96; MRXSYP |
| Reference Data | |
| Protein Categories | Membrane Proteins |
| Protein Families | Secreted Protein, Transmembrane |
Reviews
Documents
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| FAQs |
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Citations
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
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