TCCR (IL27RA) Mouse Monoclonal Antibody [Clone ID: 34N4G11]
$585.00
5 Days*
Specifications
| Product Data | |
| Clone Name | 34N4G11 |
|---|---|
| Application | CyTOF-ready, FC, IHC |
| Recommended Dilution | Flow (Cell Surface): 1 ug/ml, Immunohistochemistry: 1:10-1:500, Flow Cytometry: 1 ug/ml, Immunohistochemistry-Paraffin: 5 ug/ml, CyTOF-ready |
| Reactivity | Human |
| Antibody Host | Mouse |
| Isotype | IgG2b, kappa |
| Clonality | Monoclonal |
| Immunogen | A portion of amino acids 200-250 of human IL-27R (WSX-1) was used as the immunogen for this antibody. |
| Buffer | PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Concentration | lot specific |
| Purification | Protein G purified |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Gene Name | interleukin 27 receptor subunit alpha |
| Database Link | |
| Background | The IL-27 Receptor complex includes WSX-1 and gp130. IL-27R (WSX-1) is 65-70 kDa protein and is highly expressed in lymphoid tissues such as spleen, lymph nodes and peripheral blood leukocytes including CD4+ and CD8+ T cells, monocytes, DCs and NK cells (1-3). IL-27R activation includes STAT1, STAT3, STAT4 and STAT5, leading to differing pathway dependent effector activities. Like the IL12/IL-12R complex, the IL-27/IL-27R complex also has Th1 enhancing activity especially enhancement of IFNg production by naive T cells and NK cells (1). IL-27R mediates downregulation of Th2 activity by findings that IL-27R deficiencies mitigate inflammatory pathology in helminthic infections in mice (1, 4, 5). The possibility of utilizing IL-27R as a target for autoimmune inflammatory diseases, especially of mucosal surfaces as in human IBD, is under investigation, measured by Th2 type cytokines and bolstered through Th2 |
| Synonyms | CRL1; IL-27RA; IL27R; TCCR; WSX1; zcytor1 |
| Reference Data | |
| Protein Categories | Cytokines, Membrane Proteins |
| Protein Families | Druggable Genome, Transmembrane |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Citations
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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