TCCR (IL27RA) Mouse Monoclonal Antibody [Clone ID: 34N4G11]

SKU TA336909

Mouse Monoclonal IL-27 R alpha/WSX-1/TCCR Antibody (34N4G11)

Product Data

• Clone Name: 34N4G11
• Application: CyTOF-ready, FC, IHC
• Recommended Dilution: Flow (Cell Surface): 1 ug/ml, Immunohistochemistry: 1:10-1:500, Flow Cytometry: 1 ug/ml, Immunohistochemistry-Paraffin: 5 ug/ml, CyTOF-ready
• Reactivity: Human
• Antibody Host: Mouse
• Isotype: IgG2b, kappa
• Clonality: Monoclonal
• Immunogen: A portion of amino acids 200-250 of human IL-27R (WSX-1) was used as the immunogen for this antibody.
• Buffer: PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Concentration: lot specific
• Purification: Protein G purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Shipping: Blue Ice
• Gene Name: interleukin 27 receptor subunit alpha
• Database Link:
  NP_004834
  Q6UWB1
• Background: The IL-27 Receptor complex includes WSX-1 and gp130. IL-27R (WSX-1) is 65-70 kDa protein and is highly expressed in lymphoid tissues such as spleen, lymph nodes and peripheral blood leukocytes including CD4+ and CD8+ T cells, monocytes, DCs and NK cells (1-3). IL-27R activation includes STAT1, STAT3, STAT4 and STAT5, leading to differing pathway dependent effector activities. Like the IL12/IL-12R complex, the IL-27/IL-27R complex also has Th1 enhancing activity especially enhancement of IFNg production by naive T cells and NK cells (1). IL-27R mediates downregulation of Th2 activity by findings that IL-27R deficiencies mitigate inflammatory pathology in helminthic infections in mice (1, 4, 5). The possibility of utilizing IL-27R as a target for autoimmune inflammatory diseases, especially of mucosal surfaces as in human IBD, is under investigation, measured by Th2 type cytokines and bolstered through Th2
• Synonyms: CRL1; IL-27RA; IL27R; TCCR; WSX1; zcytor1

Reference Data

• Protein Families: Druggable Genome, Transmembrane