TRF2 (TERF2) Mouse Monoclonal Antibody [Clone ID: 4A794.15]
Specifications
| Product Data | |
| Clone Name | 4A794.15 |
|---|---|
| Application | ChIP, CyTOF-ready, ELISA, FC, ICC/IF, IHC, Immunoblotting, IP, Simple Western, WB |
| Recommended Dilution | Chromatin Immunoprecipitation (ChIP): 1:10-1:500, Immunoblotting, Western Blot: 2-4 ug/ml, ELISA: 2 ug/ml, Immunohistochemistry-Frozen: 5 ug/ml, Immunohistochemistry-Paraffin, Simple Western: 1:50, Flow Cytometry: 0.1 ug/10^6 cells, Immunohistochemistry: 1:10 - 1:500, Immunocytochemistry/ Immunofluorescence: 1:10 - 1:500, Immunoprecipitation: 2 ug/10^6 cells, CyTOF-ready, Proximity Ligation Assay |
| Reactivity | Human, Mouse, Rat |
| Antibody Host | Mouse |
| Isotype | IgG1, kappa |
| Clonality | Monoclonal |
| Immunogen | Baculovirus expressed whole length TRF2 protein was used for immunizing mice and splenocytes used to generate the hybridoma clone (NP_005643). |
| Buffer | PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Concentration | lot specific |
| Purification | Protein G purified |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Predicted Protein Size | 55.55 kDa |
| Gene Name | telomeric repeat binding factor 2 |
| Database Link | |
| Background | TRF2 is a ubiquitously expressed protein that is implicated in the control of telomere length (1). TRF2, like TRF1 contains a Myb-related DNA binding motif. It binds to duplex TTAGGG repeats and is localized to all human telomeres in metaphase chromosomes (1). TRF2 is thought to protect chromosome ends by maintaining the correct structure at telomere termini (2). The use of mutant forms of TRF2 has implicated a role for TRF2 in the prevention of senescence in primary human cells (2). Recently, it has been shown that inhibition of TRF2 resulted in apoptosis in a subset of mammalian cell types (3) |
| Synonyms | TRBF2; TRF2 |
| Note | 1. TLR2 may be detected as a single band or as a doublet in western blot. Okabe (2000) described the doublet as 65 and 69 kDa using clone 4A794.15. However, observed molecular weights could vary depending on molecular weight standards used and gel conditions. 2. The TRF2 antibody is referred to as both clone 4A794.15 and 4A794 in the published literature. 3. The TRF2 antibody recognizes full-length TRF2 as well as TRF2 forms lacking both the N-terminal basic domain (B) and the telobox Myb-like C-terminal DNA-binding domain (M). TRF2 forms missing the B and M domains are often referred to as mutant TRF2. Refer to the published literature for additional information. 4. Although the exact epitope recognized by the TRF2 antibody has not been mapped, the scientific literature indicates it is in the D or L domain, but not in the B or M domain. |
| Reference Data | |
| Protein Categories | Intracellular Proteins |
| Protein Families | Transcription Factors |
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Citations
Association of TRF2 expression and myeloid-derived suppressor cells infiltration with clinical outcome of patients with cutaneous melanoma
Ilié, Lantéri, Chamorey et al
Oncoimmunology (2021) 10 (1), 1901446 DOI: 10.1080/2162402X.2021.1901446
Ilié, Lantéri, Chamorey et al
Oncoimmunology (2021) 10 (1), 1901446 DOI: 10.1080/2162402X.2021.1901446
AI Summary: In this study, OriGene products—specifically the anti-TRF2 antibody (TA500439) and the anti-CD33 antibody (TA506535)—were used for immunohistochemical detection and quantification of TRF2 and CD33+ cells in melanoma tissue samples, enabling the assessment of their association with patient clinical outcomes.
Showing 1-1 of 1 papers.
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